Literature DB >> 2721671

Characterization of purinoceptors present on human liver plasma membranes.

S Keppens1, A Vandekerckhove, H De Wulf.   

Abstract

Using ATP alpha 35S as radioligand, we have detected the presence of specific purinoceptors on human liver plasma membranes. They are characterized by a Kd value of 0.19 microM and a Bmax of 24 pmol/mg membrane protein. These purinoceptors belong to the P2Y subclass as demonstrated by the high degree of similarity with rat liver purinoceptors, previously shown to be P2Y [(1986) Biochem. J. 240, 367-371] and known to be involved in the control of liver glycogenolysis.

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Year:  1989        PMID： 2721671     DOI： 10.1016/0014-5793(89)80448-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  High- and low-affinity binding sites for [3H]-alpha, beta-methylene ATP in rat urinary bladder membranes.

Authors:  X N Bo; G Burnstock
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

2.  Characterization of the binding of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to rat liver cell membranes.

Authors:  M Edgecombe; A G McLennan; M J Fisher
Journal:  Biochem J       Date:  1996-03-01       Impact factor: 3.857

3.  Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8.

Authors:  Michel Fausther; Joanna Lecka; Filip Kukulski; Sébastien A Lévesque; Julie Pelletier; Herbert Zimmermann; Jonathan A Dranoff; Jean Sévigny
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2006-11-09       Impact factor: 4.052

Review 4.  The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism.

Authors:  Guido Beldi; Keiichi Enjyoji; Yan Wu; Lindsay Miller; Yara Banz; Xiaofeng Sun; Simon C Robson
Journal:  Front Biosci       Date:  2008-01-01

5.  Ap4A and ADP-beta-S binding to P2 purinoceptors present on rat brain synaptic terminals.

Authors:  J Pintor; M A Díaz-Rey; M T Miras-Portugal
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

6.  Characterization of the biological effects of 2-methylthio-ATP on rat hepatocytes: clear-cut differences with ATP.

Authors:  S Keppens; H De Wulf
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

7.  Characterization of the effects of adenosine 5'-[beta-thio]-diphosphate in rat liver.

Authors:  S Keppens; A Vandekerckhove; H De Wulf
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

8.  Characterization of diadenosine tetraphosphate (Ap4A) binding sites in cultured chromaffin cells: evidence for a P2y site.

Authors:  J Pintor; M Torres; E Castro; M T Miras-Portugal
Journal:  Br J Pharmacol       Date:  1991-08       Impact factor: 8.739

9.  Potentiation of miniature endplate potential frequency by ATP in Xenopus tadpoles.

Authors:  W M Fu; S H Yang; S Y Lin-Shiau
Journal:  Br J Pharmacol       Date:  1993-01       Impact factor: 8.739

Review 10.  Purinergic signalling in the liver in health and disease.

Authors:  Geoffrey Burnstock; Byron Vaughn; Simon C Robson
Journal:  Purinergic Signal       Date:  2013-11-24       Impact factor: 3.765
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