| Literature DB >> 27216623 |
Fanpeng Kong1, Ziye Liang1, Dongrui Luan1, Xiaojun Liu1, Kehua Xu1, Bo Tang1.
Abstract
To reduce the side effects of chemotherapy, nontoxic prodrugs activated by the tumor microenvironment are urgently required for use in cancer treatment. In this work, we developed prodrug 4 for tumor-targeting treatment and imaging of the anticancer drug release in vivo. Taking advantage of the high glutathione (GSH) concentration in cancer cells, the disulfide bond in prodrug 4 was cleaved, resulting in the release of an active anticancer drug and a near-infrared (NIR) fluorescence dye turn-on. Furthermore, contrast to the free anticancer drug, the prodrug exhibited higher cytotoxicity to hepatoma cells than that to normal HL-7702 cells. Thus, prodrug 4 is a promising platform for specific tumor-activatable drug delivery system, because of its favorable features of in situ and in vivo monitoring of the drug release and therapeutic efficacy.Entities:
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Year: 2016 PMID： 27216623 DOI： 10.1021/acs.analchem.6b01135
Source DB: PubMed Journal: Anal Chem ISSN： 0003-2700 Impact factor: 6.986