Literature DB >> 2721640

Decreased number of asialoglycoprotein receptors in diabetic BB Wistar rat.

P Scarmato1, C Cherqui-Eisenberg, G Durand, J Feger.   

Abstract

The binding of asialoglycoproteins by hepatic binding protein was studied in freshly isolated hepatocytes from genetically diabetic BB Wistar rats. The number of cell surface asialoglycoprotein receptors was dramatically decreased (58,000 +/- 38,000 for diabetic rats compared to 267,000 +/- 70,000 for normal rats), while the association equilibrium constant was not changed. These results parallel those obtained with streptozotocin-diabetic rats and support the hypothesis that insulin deprivation is responsible for the decrease in the receptor number.

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Year:  1989        PMID： 2721640     DOI： 10.1007/BF01952038

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Ligand: a versatile computerized approach for characterization of ligand-binding systems.

Authors:  P J Munson; D Rodbard
Journal:  Anal Biochem       Date:  1980-09-01       Impact factor: 3.365

Review 2.  The hepatic asialoglycoprotein receptor.

Authors:  A L Schwartz
Journal:  CRC Crit Rev Biochem       Date:  1984

3.  Effects of streptozotocin-induced diabetes mellitus on the binding and uptake of asialoorosomucoïd by isolated hepatocytes from rats.

Authors:  M Dodeur; D Durand; J Dumont; G Durand; J Feger; J Agneray
Journal:  Eur J Biochem       Date:  1982-04-01

Review 4.  The diabetic syndrome of the 'BB' Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man.

Authors:  E B Marliss; A F Nakhooda; P Poussier; A A Sima
Journal:  Diabetologia       Date:  1982-04       Impact factor: 10.122

5.  Lilly Lecture 1979: role of insulin in the regulation of protein synthesis.

Authors:  L S Jefferson
Journal:  Diabetes       Date:  1980-06       Impact factor: 9.461

6.  The effect of diabetes on hepatocyte plasma membrane fluidity and concanavalin A-induced agglutination.

Authors:  K Nassar; S Cheng; D Levy
Journal:  Exp Cell Res       Date:  1981-03       Impact factor: 3.905

7.  Isolation, culture, and transplantation of human hepatocytes.

Authors:  S C Strom; R L Jirtle; R S Jones; D L Novicki; M R Rosenberg; A Novotny; G Irons; J R McLain; G Michalopoulos
Journal:  J Natl Cancer Inst       Date:  1982-05       Impact factor: 13.506

8.  The spontaneously diabetic Wistar rat. Metabolic and morphologic studies.

Authors:  A F Nakhooda; A A Like; C I Chappel; F T Murray; E B Marliss
Journal:  Diabetes       Date:  1977-02       Impact factor: 9.461

9.  Kinetic evidence of a surface membraneous step during the endocytosic process of 3H-labelled asialoorosomucoid and its alteration in diabetic mellitus rats.

Authors:  P Scarmato; J Feger; M Dodeur; G Durand; J Agneray
Journal:  Biochim Biophys Acta       Date:  1985-11-22

10.  Diabetes-induced variation in hepatic binding protein.

Authors:  M Dodeur; S Coumoul; D Durand; G Durand; J Feger; J Agneray
Journal:  Biochem Biophys Res Commun       Date:  1983-08-30       Impact factor: 3.575
  10 in total

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