Literature DB >> 27216293

JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium.

Kazunori Gomi1, Michelle R Staudt1, Jacqueline Salit1, Robert J Kaner1, Jonna Heldrich1, Allison M Rogalski1, Vanessa Arbelaez1, Ronald G Crystal1, Matthew S Walters2.   

Abstract

Basal cells (BC) are the stem/progenitor cells of the human airway epithelium capable of differentiating into secretory and ciliated cells. Notch signaling activation increases BC differentiation into secretory cells, but the role of individual Notch ligands in regulating this process in the human airway epithelium is largely unknown. The objective of this study was to define the role of the Notch ligand JAG1 in regulating human BC differentiation. JAG1 over-expression in BC increased secretory cell differentiation, with no effect on ciliated cell differentiation. Conversely, knockdown of JAG1 decreased expression of secretory cell genes. These data demonstrate JAG1-mediated Notch signaling regulates differentiation of BC into secretory cells.

Entities:  

Keywords:  Basal stem/progenitor cells; Differentiation; Human airway epithelium; JAG1; Notch signaling

Mesh：

Substances：

Year:  2016        PMID： 27216293      PMCID： PMC4926772          DOI： 10.1007/s12015-016-9656-6

Source DB:  PubMed          Journal:  Stem Cell Rev Rep        ISSN： 2629-3277            Impact factor:   5.739


  44 in total

Review 1.  Cellular and molecular characteristics of basal cells in airway epithelium.

Authors:  M J Evans; L S Van Winkle; M V Fanucchi; C G Plopper
Journal:  Exp Lung Res       Date:  2001 Jul-Aug       Impact factor: 2.459

Review 2.  Airway epithelial cells: current concepts and challenges.

Authors:  Ronald G Crystal; Scott H Randell; John F Engelhardt; Judith Voynow; Mary E Sunday
Journal:  Proc Am Thorac Soc       Date:  2008-09-15

3.  Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.

Authors:  Lin Shan; Jon C Aster; Jeffrey Sklar; Mary E Sunday
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2006-10-06       Impact factor: 5.464

Review 4.  Notch signaling in the regulation of stem cell self-renewal and differentiation.

Authors:  Jianing Liu; Chihiro Sato; Massimiliano Cerletti; Amy Wagers
Journal:  Curr Top Dev Biol       Date:  2010       Impact factor: 4.897

5.  NOTCH1 is required for regeneration of Clara cells during repair of airway injury.

Authors:  Yiming Xing; Aimin Li; Zea Borok; Changgong Li; Parviz Minoo
Journal:  Stem Cells       Date:  2012-05       Impact factor: 6.277

6.  Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease.

Authors:  Ann E Tilley; Ben-Gary Harvey; Adriana Heguy; Neil R Hackett; Rui Wang; Timothy P O'Connor; Ronald G Crystal
Journal:  Am J Respir Crit Care Med       Date:  2008-12-23       Impact factor: 21.405

7.  Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate.

Authors:  Mitsuru Morimoto; Zhenyi Liu; Hui-Teng Cheng; Niki Winters; David Bader; Raphael Kopan
Journal:  J Cell Sci       Date:  2010-01-15       Impact factor: 5.285

8.  Airway-specific inducible transgene expression using aerosolized doxycycline.

Authors:  Purushothama Rao Tata; Ana Pardo-Saganta; Mythili Prabhu; Vladimir Vinarsky; Brandon M Law; Benjamin A Fontaine; Andrew M Tager; Jayaraj Rajagopal
Journal:  Am J Respir Cell Mol Biol       Date:  2013-12       Impact factor: 6.914

9.  The human airway epithelial basal cell transcriptome.

Authors:  Neil R Hackett; Renat Shaykhiev; Matthew S Walters; Rui Wang; Rachel K Zwick; Barbara Ferris; Bradley Witover; Jacqueline Salit; Ronald G Crystal
Journal:  PLoS One       Date:  2011-05-04       Impact factor: 3.240

10.  Parent stem cells can serve as niches for their daughter cells.

Authors:  Ana Pardo-Saganta; Purushothama Rao Tata; Brandon M Law; Borja Saez; Ryan Dz-Wei Chow; Mythili Prabhu; Thomas Gridley; Jayaraj Rajagopal
Journal:  Nature       Date:  2015-07-06       Impact factor: 49.962
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  7 in total

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Authors:  Manish Bodas; Andrew R Moore; Bharathiraja Subramaniyan; Constantin Georgescu; Jonathan D Wren; Willard M Freeman; Brent R Brown; Jordan P Metcalf; Matthew S Walters
Journal:  Am J Respir Cell Mol Biol       Date:  2021-04       Impact factor: 6.914

2.  Notch Signaling between Cerebellar Granule Cell Progenitors.

Authors:  Toma Adachi; Satoshi Miyashita; Mariko Yamashita; Mana Shimoda; Konstantin Okonechnikov; Lukas Chavez; Marcel Kool; Stefan M Pfister; Takafumi Inoue; Daisuke Kawauchi; Mikio Hoshino
Journal:  eNeuro       Date:  2021-05-12

3.  Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia.

Authors:  Wen-Cheng Chung; Yunyun Zhou; Azeddine Atfi; Keli Xu
Journal:  Neoplasia       Date:  2019-07-02       Impact factor: 5.715

4.  The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation.

Authors:  Manish Bodas; Bharathiraja Subramaniyan; Andrew R Moore; Jordan P Metcalf; Sarah R Ocañas; Willard M Freeman; Constantin Georgescu; Jonathan D Wren; Matthew S Walters
Journal:  Cells       Date:  2021-11-18       Impact factor: 7.666

5.  Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease.

Authors:  Susan D Reynolds; Cynthia L Hill; Alfahdah Alsudayri; Scott W Lallier; Saranga Wijeratne; Zheng Hong Tan; Tendy Chiang; Estelle Cormet-Boyaka
Journal:  JCI Insight       Date:  2022-08-08

6.  Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.

Authors:  J M Sweeter; K Kudrna; K Hunt; P Thomes; B F Dickey; S L Brody; J D Dickinson
Journal:  Sci Rep       Date:  2021-06-22       Impact factor: 4.379

7.  Join or Leave the Club: Jagged1 and Notch2 Dictate the Fate of Airway Epithelial Cells.

Authors:  Virinchi N S Kuchibhotla; Irene H Heijink
Journal:  Am J Respir Cell Mol Biol       Date:  2020-07       Impact factor: 6.914
  7 in total

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