Literature DB >> 2721579

Inhibitory histamine H3-receptors on cholinergic nerves in human airways.

M Ichinose1, P J Barnes.   

Abstract

The histamine H3-agonist, (R)-alpha-methylhistamine (alpha-MeHA) caused a dose-dependent inhibition of cholinergic contractile responses to electrical field stimulation in human bronchi without affecting the basal tone. alpha-MeHA, but, did not alter the response to acetylcholine. Blockade of H1- and H2-receptors, or alpha- and beta-adrenoceptors failed to prevent the inhibitory effect of alpha-MeHA, whereas the specific H3-antagonist, thioperamide, was effective. Our results indicate that H3-receptors modulate cholinergic neurotransmission in human airways.

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Year:  1989        PMID： 2721579     DOI： 10.1016/0014-2999(89)90212-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


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