Literature DB >> 27215467

GPR55: Metabolic Help or Hindrance?

Christopher M Henstridge1, Andrew J Brown2, Maria Waldhoer3.   

Abstract

Since the discovery of the lysophospholipid-sensitive receptor GPR55, hopes have been raised that targeting this G protein-coupled receptor (GPCR) may represent a novel approach for the treatment of metabolic disorders. We discuss conflicting evidence surrounding GPR55 physiology and highlight its potential as a novel target for the treatment of obesity and diabetes.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GPR55; LPI; diabetes; metabolism; obesity

Mesh：

Substances：

Year:  2016        PMID： 27215467     DOI： 10.1016/j.tem.2016.04.012

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  5 in total

1.  High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain.

Authors:  Edward T Wargent; Malgorzata Kepczynska; Mohamed Sghaier Zaibi; David C Hislop; Jonathan R S Arch; Claire J Stocker
Journal:  PeerJ       Date:  2020-08-24       Impact factor: 2.984

Review 2.  Endocannabinoids in the Islets of Langerhans: the ugly, the bad, and the good facts.

Authors:  Isabel González-Mariscal; Josephine M Egan
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-04-06       Impact factor: 4.310

3.  The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis.

Authors:  Marcos F Fondevila; Uxia Fernandez; Maria J Gonzalez-Rellan; Natalia Da Silva Lima; Xabier Buque; Agueda Gonzalez-Rodriguez; Cristina Alonso; Marta Iruarrizaga-Lejarreta; Teresa C Delgado; Marta Varela-Rey; Ana Senra; Vera Garcia-Outeiral; Eva Novoa; Cristina Iglesias; Begoña Porteiro; Daniel Beiroa; Cintia Folgueira; Marta Tojo; Jorge L Torres; Lourdes Hernández-Cosido; Óscar Blanco; Juan Pablo Arab; Francisco Barrera; Diana Guallar; Miguel Fidalgo; Miguel López; Carlos Dieguez; Miguel Marcos; Maria L Martinez-Chantar; Marco Arrese; Carmelo Garcia-Monzon; Jose M Mato; Patricia Aspichueta; Ruben Nogueiras
Journal:  Hepatology       Date:  2020-11-13       Impact factor: 17.425

4.  Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling.

Authors:  Sarah-Lena Puhl; Michael Hilby; Michael Kohlhaas; Linus M Keidel; Yvonne Jansen; Michael Hristov; Jakob Schindler; Christoph Maack; Sabine Steffens
Journal:  Sci Rep       Date:  2021-07-13       Impact factor: 4.379

5.  Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma.

Authors:  Thangesweran Ayakannu; Anthony H Taylor; Justin C Konje
Journal:  Histochem Cell Biol       Date:  2021-07-29       Impact factor: 4.304
  5 in total

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