Literature DB >> 27215128

Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity.

Ye-Kun Yang1, Si-da Xie2, Wan-Xuan Xu2, Yin Nian2, Xiao-Ling Liu2, Xing-Rong Peng2, Zhong-Tao Ding3, Ming-Hua Qiu4.   

Abstract

Six new physalin steroids, 7β-methoxylisophysalin B (1), 7β-methoxylphysalin C (2), physalin V (3), physalin VI (4), physalin VII (5), isophysalin I (6), together with 20 known physalins (7-26) were isolated from calyces of Physalis alkekengi var. franchetii. Structures of the new compounds were revealed through 1D and 2D NMR and mass spectroscopic methods. Compounds 1-26 were evaluated for cytotoxicity against human HL-60, SMMC-7721, A-549, MCF-7 and SW-480, and the results indicated that compounds 8, 11, and 14 displayed potent cytotoxicities (IC50<5μM) in vitro. Further antibacterial assay indicated that compounds 8, 14, and 19 showed high antibacterial activities against Bacillus subtilis and Escherichia coli.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Neophysalin; Physalin; Physalin B (PubChem CID: 431000); Physalin F (PubChem CID: 49864133); Physalis alkekengi var. franchetii; Steroid

Mesh：

Substances：

Year:  2016        PMID： 27215128     DOI： 10.1016/j.fitote.2016.05.010

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  7 in total

1.  Stereo- and region-specific biotransformation of physapubescin by four fungal strains.

Authors:  Chongyue Qiu; Ting Yuan; Dejuan Sun; Suyu Gao; Lixia Chen
Journal:  J Nat Med       Date:  2017-01-10       Impact factor: 2.343

Review 2.  Therapeutic Applications of Physalins: Powerful Natural Weapons.

Authors:  Cássio Santana Meira; José Waldson Capinan Soares; Bruna Padilha Zurita Claro Dos Reis; Luciano Vasconcellos Pacheco; Ivanilson Pimenta Santos; Dahara Keyse Carvalho Silva; Julia Costa de Lacerda; Sérgio Ricardo Teixeira Daltro; Elisalva Teixeira Guimarães; Milena Botelho Pereira Soares
Journal:  Front Pharmacol       Date:  2022-04-05       Impact factor: 5.988

3.  Anti-Inflammatory Effect of Three Isolated Compounds of Physalis alkekengi var. franchetii (PAF) in Lipopolysaccharide-Activated RAW 264.7 Cells.

Authors:  Hyun-Jung Park; Hyun Soo Shim; Ah-Reum Han; Eun-Kyoung Seo; Kyu-Ri Kim; Bong Hee Han; Insop Shim
Journal:  Curr Issues Mol Biol       Date:  2022-03-21       Impact factor: 2.976

4.  Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B.

Authors:  Jian Xu; Yihua Wu; Guang Lu; Shujun Xie; Zhongjun Ma; Zhe Chen; Han-Ming Shen; Dajing Xia
Journal:  Redox Biol       Date:  2017-02-24       Impact factor: 11.799

5.  Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities.

Authors:  Cheng-Peng Sun; Chong-Yue Qiu; Feng Zhao; Ning Kang; Li-Xia Chen; Feng Qiu
Journal:  Sci Rep       Date:  2017-06-22       Impact factor: 4.379

6.  Development of Species-Specific SCAR Markers, Based on a SCoT Analysis, to Authenticate Physalis (Solanaceae) Species.

Authors:  Shangguo Feng; Yujia Zhu; Chenliang Yu; Kaili Jiao; Mengying Jiang; Jiangjie Lu; Chenjia Shen; Qicai Ying; Huizhong Wang
Journal:  Front Genet       Date:  2018-05-29       Impact factor: 4.599

Review 7.  Natural Products from Physalis alkekengi L. var. franchetii (Mast.) Makino: A Review on Their Structural Analysis, Quality Control, Pharmacology, and Pharmacokinetics.

Authors:  Jing Yang; Yanping Sun; Feng Cao; Bingyou Yang; Haixue Kuang
Journal:  Molecules       Date:  2022-01-21       Impact factor: 4.411
  7 in total

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