Literature DB >> 27214150

Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis.

Mingfeng Yu1, Gayathri Nagalingam2, Samantha Ellis2, Elena Martinez3, Vitali Sintchenko3, Malcolm Spain1, Peter J Rutledge1, Matthew H Todd1, James A Triccas2.   

Abstract

Tuberculosis (TB) accounted for 1.5 million deaths in 2014, and new classes of anti-TB drugs are required. We report a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against pathogenic mycobacteria. These compounds inhibit intracellular growth of Mycobacterium tuberculosis, are nontoxic to human cell lines, and are active against multidrug-resistant M. tuberculosis strains, indicating a distinct mode of action. These compounds warrant further appraisal as novel agents to control TB in humans.

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Year:  2016        PMID： 27214150     DOI： 10.1021/acs.jmedchem.6b00432

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit.

Authors:  Lisa Barbaro; Gayathri Nagalingam; James A Triccas; Lendl Tan; Nicholas P West; Jonathan B Baell; Daniel L Priebbenow
Journal:  RSC Med Chem       Date:  2021-05-07

2.  A direct method for the N-tetraalkylation of azamacrocycles.

Authors:  Andrew J Counsell; Angus T Jones; Matthew H Todd; Peter J Rutledge
Journal:  Beilstein J Org Chem       Date:  2016-11-18       Impact factor: 2.883

3.  Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis.

Authors:  Diana H Quan; Gayathri Nagalingam; Ian Luck; Nicholas Proschogo; Vijaykumar Pillalamarri; Anthony Addlagatta; Elena Martinez; Vitali Sintchenko; Peter J Rutledge; James A Triccas
Journal:  Sci Rep       Date:  2019-10-07       Impact factor: 4.379

4.  Investigations into the Structure/Antibacterial Activity Relationships of Cyclam and Cyclen Derivatives.

Authors:  Luis G Alves; João F Portel; Sílvia A Sousa; Olga Ferreira; Stephanie Almada; Elisabete R Silva; Ana M Martins; Jorge H Leitão
Journal:  Antibiotics (Basel)       Date:  2019-11-14

5.  Synthesis and Evaluation of 1,8-Disubstituted-Cyclam/Naphthalimide Conjugates as Probes for Metal Ions.

Authors:  Joseph K-H Wong; Sandra Ast; Mingfeng Yu; Roman Flehr; Andrew J Counsell; Peter Turner; Patrick Crisologo; Matthew H Todd; Peter J Rutledge
Journal:  ChemistryOpen       Date:  2016-08-03       Impact factor: 2.911

6.  Metal complexes as a promising source for new antibiotics.

Authors:  Angelo Frei; Johannes Zuegg; Alysha G Elliott; Murray Baker; Stefan Braese; Christopher Brown; Feng Chen; Christopher G Dowson; Gilles Dujardin; Nicole Jung; A Paden King; Ahmed M Mansour; Massimiliano Massi; John Moat; Heba A Mohamed; Anna K Renfrew; Peter J Rutledge; Peter J Sadler; Matthew H Todd; Charlotte E Willans; Justin J Wilson; Matthew A Cooper; Mark A T Blaskovich
Journal:  Chem Sci       Date:  2020-02-12       Impact factor: 9.825
  6 in total

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