| Literature DB >> 27214143 |
Skander Hathroubi1, Mohamed A Mekni2, Philip Domenico3, Dao Nguyen4, Mario Jacques1.
Abstract
Biofilms are communities of aggregated bacterial cells embedded in a self-produced extracellular polymeric matrix. Biofilms are recalcitrant to antibiotic treatment and immune defenses and are implicated in many chronic bacterial and fungal infections. In this review, we provide an overview of the contribution of biofilms to persistent infections resistant to antibiotic treatment, the impact of multispecies biofilms on drug resistance and tolerance, and recent advances in the development of antibiofilm agents. Understanding the mechanisms of antibiotic resistance and tolerance in biofilms is essential for developing new preventive and therapeutic strategies and curbing drug resistance.Entities:
Keywords: anti-biofilm agents; antibiotic resistance; antibiotic tolerance; biofilm
Mesh:
Substances:
Year: 2016 PMID: 27214143 DOI: 10.1089/mdr.2016.0087
Source DB: PubMed Journal: Microb Drug Resist ISSN: 1076-6294 Impact factor: 3.431