J-H Zhang1, H-W Wei, H-G Yang. 1. Department of Clinical Laboratory, Linyi People's Hospital, Linyi, Shandong, China. YYLP147@163.com.
Abstract
OBJECTIVE: The purpose of this study was to investigate the expression of lncRNA SNHG15 and its prognostic value in hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Expression levels of lncRNA SNHG15 in 152 pairs of HCC tissues and adjacent normal tissues were detected by quantitative real-time PCR. Associations between clinicopathological parameters and lncRNA SNHG15 expression were evaluated using chi-square tests. The overall survival was analyzed by log-rank test, and survival curves were plotted according to Kaplan-Meier. Univariate and multivariate Cox regression analyses were conducted to determine whether lncRNA SNHG15 was an independent predictor of survival. RESULTS: The lncRNA SNHG15 expression was significantly upregulated in tumor tissues compared with that in adjacent non-tumor tissues (p < 0.01). It is also proved that lncRNA SNHG15 expression was associated with histological grade (p = 0.000), TNM stage (p = 0.015), and vein invasion (p = 0.000). In addition, Kaplan-Meier analysis showed that increased LncRNA SNHG15 expression was associated with poor overall survival of patients (p = 0.0011). Moreover, the results of the multivariate analysis showed that high lncRNA SNHG15 expression was a significant independent predictor of poor survival in HCC (p < 0.05). CONCLUSIONS: Our findings suggest that lncRNA SNHG15 may serve as an efficient clinical biomarker and a therapeutic target for HCC patients.
OBJECTIVE: The purpose of this study was to investigate the expression of lncRNA SNHG15 and its prognostic value in hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Expression levels of lncRNA SNHG15 in 152 pairs of HCC tissues and adjacent normal tissues were detected by quantitative real-time PCR. Associations between clinicopathological parameters and lncRNA SNHG15 expression were evaluated using chi-square tests. The overall survival was analyzed by log-rank test, and survival curves were plotted according to Kaplan-Meier. Univariate and multivariate Cox regression analyses were conducted to determine whether lncRNA SNHG15 was an independent predictor of survival. RESULTS: The lncRNA SNHG15 expression was significantly upregulated in tumor tissues compared with that in adjacent non-tumor tissues (p < 0.01). It is also proved that lncRNA SNHG15 expression was associated with histological grade (p = 0.000), TNM stage (p = 0.015), and vein invasion (p = 0.000). In addition, Kaplan-Meier analysis showed that increased LncRNA SNHG15 expression was associated with poor overall survival of patients (p = 0.0011). Moreover, the results of the multivariate analysis showed that high lncRNA SNHG15 expression was a significant independent predictor of poor survival in HCC (p < 0.05). CONCLUSIONS: Our findings suggest that lncRNA SNHG15 may serve as an efficient clinical biomarker and a therapeutic target for HCC patients.
Authors: Ronan Flippot; Roger Mouawad; Jean-Philippe Spano; Morgan Rouprêt; Eva Compérat; Marc-Olivier Bitker; Jérôme Parra; Christophe Vaessen; Frederick Allanic; Quentin Manach; Nizar M Tannir; David Khayat; Xiaoping Su; Gabriel G Malouf Journal: Sci Rep Date: 2017-08-17 Impact factor: 4.379