| Literature DB >> 27211490 |
Atsushi Umemura1, Feng He2, Koji Taniguchi3, Hayato Nakagawa4, Shinichiro Yamachika2, Joan Font-Burgada2, Zhenyu Zhong2, Shankar Subramaniam5, Sindhu Raghunandan5, Angeles Duran6, Juan F Linares6, Miguel Reina-Campos6, Shiori Umemura7, Mark A Valasek8, Ekihiro Seki9, Kanji Yamaguchi10, Kazuhiko Koike11, Yoshito Itoh10, Maria T Diaz-Meco6, Jorge Moscat12, Michael Karin13.
Abstract
p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate in the formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was not explored. Here we show that p62 is necessary and sufficient for HCC induction in mice and that its high expression in non-tumor human liver predicts rapid HCC recurrence after curative ablation. High p62 expression is needed for activation of NRF2 and mTORC1, induction of c-Myc, and protection of HCC-initiating cells from oxidative stress-induced death.Entities:
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Year: 2016 PMID： 27211490 PMCID： PMC4907799 DOI： 10.1016/j.ccell.2016.04.006
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743