Seung Hyun Lee1, Young Han Lee2, Seok Hahn3, Jin-Suck Suh4. 1. Department of Radiology, Research Institute of Radiological Science, Medical Convergence Research Institute, and Severance Biomedical Science Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. Electronic address: circle1128@yuhs.ac. 2. Department of Radiology, Research Institute of Radiological Science, Medical Convergence Research Institute, and Severance Biomedical Science Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. Electronic address: sando@yuhs.ac. 3. Department of Radiology, Research Institute of Radiological Science, Medical Convergence Research Institute, and Severance Biomedical Science Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. Electronic address: andrew0668@yuhs.ac. 4. Department of Radiology, Research Institute of Radiological Science, Medical Convergence Research Institute, and Severance Biomedical Science Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. Electronic address: jss@yuhs.ac.
Abstract
PURPOSE: This study aims to compare fat fraction of lumbar vertebrae between cancer and non-cancer patients, using the two-point modified Dixon (mDixon) turbo spin-echo (TSE) MRI with flexible echo times and multipeak fat spectral model. MATERIALS AND METHODS: Fat fraction was calculated from fat and water images reconstructed by the mDixon TSE technique. Fat fraction of fat-water phantoms measured with the mDixon TSE method was compared with actual fat percentages. Patients who had undergone mDixon spine MRI and dual-energy X-ray absorptiometry within one year and had no bone metastasis were divided into cancer (n=7) and non-cancer (n=23) groups. Fat fraction and bone mineral density (BMD) were compared between the two groups. RESULTS: Fat fraction of phantoms measured with mDixon MRI was highly correlated with their actual fat percentages (P<0.01, R(2)=0.93). Fat fraction of lumbar vertebrae was significantly lower in cancer patients (58.27±3.16%) than in non-cancer patients (70.48±1.83%) (P<0.01). BMD was not different between cancer (0.912±0.057g/cm(2)) and non-cancer patients (0.876±0.032g/cm(2)) (P=0.58). Fat fraction and BMD showed no significant correlation (P=0.95, R=0.006). CONCLUSIONS: A two-point mDixon TSE method for assessing fat fraction was reliable. Fat fraction of morphologically normal lumbar vertebrae was significantly lower in cancer patients compared to non-cancer patients, using the two-point mDixon TSE technique.
PURPOSE: This study aims to compare fat fraction of lumbar vertebrae between cancer and non-cancerpatients, using the two-point modified Dixon (mDixon) turbo spin-echo (TSE) MRI with flexible echo times and multipeak fat spectral model. MATERIALS AND METHODS: Fat fraction was calculated from fat and water images reconstructed by the mDixon TSE technique. Fat fraction of fat-water phantoms measured with the mDixon TSE method was compared with actual fat percentages. Patients who had undergone mDixon spine MRI and dual-energy X-ray absorptiometry within one year and had no bone metastasis were divided into cancer (n=7) and non-cancer (n=23) groups. Fat fraction and bone mineral density (BMD) were compared between the two groups. RESULTS: Fat fraction of phantoms measured with mDixon MRI was highly correlated with their actual fat percentages (P<0.01, R(2)=0.93). Fat fraction of lumbar vertebrae was significantly lower in cancerpatients (58.27±3.16%) than in non-cancerpatients (70.48±1.83%) (P<0.01). BMD was not different between cancer (0.912±0.057g/cm(2)) and non-cancerpatients (0.876±0.032g/cm(2)) (P=0.58). Fat fraction and BMD showed no significant correlation (P=0.95, R=0.006). CONCLUSIONS: A two-point mDixon TSE method for assessing fat fraction was reliable. Fat fraction of morphologically normal lumbar vertebrae was significantly lower in cancerpatients compared to non-cancerpatients, using the two-point mDixon TSE technique.
Authors: Sebastien Bacher; Steven David Hajdu; Yael Maeder; Vincent Dunet; Tom Hilbert; Patrick Omoumi Journal: Eur Radiol Date: 2021-05-26 Impact factor: 5.315