| Literature DB >> 27211036 |
Zainab Ahdash1, Euan Pyle2, Argyris Politis3.
Abstract
A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.Keywords: conformational states; hybrid approaches; integrative modelling; mass spectrometry; protein complexes
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Year: 2016 PMID： 27211036 DOI： 10.1016/j.tibs.2016.04.008
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807