| Literature DB >> 27210797 |
En-Jun Gao1, Shaozhong Zhang2, Yang Meng2, Fu-Chen Zhao2, Xiao-Yu Ma2, Hai-Tao Jin2, Si-Jia Liu2, Jing Ge2, Ya-Guang Sun2, Wan-Zhong Zhang2, Ming-Chang Zhu3.
Abstract
Two new zinc complexes, namely Zn(L(1))ClCH2NO(1) and {Zn(L(2))CH2NO}n▪N(CH3)3▪ClO4(2) (L(1) = 3,5-di(1H-imidazol-1-yl)pyridine L(2) = 1,3,5-tris(1-imidazolyl) benzene), have been synthesized, and characterized by IR spectra, elemental analysis, and a single crystal X-ray diffraction. Fluorescence spectroscopy indicated that two complexes presented strong DNA binding affinity constants to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic study showed the complex exhibited significant cancer cell(KB) inhibitory rate.Entities:
Keywords: 1,3,5-tris(1-imidazolyl)benzene; 3,5-di(1H-imidazol-1-yl)pyridine; Cancer cell inhibition; Crystal structure
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Year: 2016 PMID： 27210797 DOI： 10.1007/s10895-016-1820-5
Source DB: PubMed Journal: J Fluoresc ISSN： 1053-0509 Impact factor: 2.217