Literature DB >> 27210436

The synthesis and synergistic antifungal effects of chalcones against drug resistant Candida albicans.

Yuan-Hua Wang1, Huai-Huai Dong2, Fei Zhao2, Jie Wang3, Fang Yan3, Yuan-Ying Jiang4, Yong-Sheng Jin5.   

Abstract

To identify effective and low toxicity synergistic antifungal compounds, 24 derivatives of chalcone were synthesized to restore the effectiveness of fluconazole against fluconazole-resistant Candida albicans. The minimal inhibitory concentration (MIC80) and the fractional inhibitory concentration index (FICI) of the antifungal synergist fluconazole were measured against fluconazole-resistant Candida albicans. This was done via methods established by the clinical and laboratory standards institute (CLSI). Of the synthesized compounds, 2'-hydroxy-4'-methoxychalcone (8) exhibited the most potent in vitro (FICI=0.007) effects. The structure activity relationship of the compounds are then discussed.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antifungal effect; Candida albicans; Chalcone; Fluconazole; Synergist

Mesh：

Substances：

Year:  2016        PMID： 27210436     DOI： 10.1016/j.bmcl.2016.05.013

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

Review 1.  Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics.

Authors:  Konstantin A Demin; Aleksandr G Refeld; Anna A Bogdanova; Evgenya V Prazdnova; Igor V Popov; Olga Yu Kutsevalova; Alexey M Ermakov; Anzhelica B Bren; Dmitry V Rudoy; Vladimir A Chistyakov; Richard Weeks; Michael L Chikindas
Journal:  Probiotics Antimicrob Proteins       Date:  2021-03-18       Impact factor: 4.609

Review 2.  Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis.

Authors:  Liliana Scorzoni; Ana C A de Paula E Silva; Caroline M Marcos; Patrícia A Assato; Wanessa C M A de Melo; Haroldo C de Oliveira; Caroline B Costa-Orlandi; Maria J S Mendes-Giannini; Ana M Fusco-Almeida
Journal:  Front Microbiol       Date:  2017-01-23       Impact factor: 5.640

3.  Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines.

Authors:  Addila Abu Bakar; Muhammad Nadeem Akhtar; Norlaily Mohd Ali; Swee Keong Yeap; Ching Kheng Quah; Wan-Sin Loh; Noorjahan Banu Alitheen; Seema Zareen; Zaheer Ul-Haq; Syed Adnan Ali Shah
Journal:  Molecules       Date:  2018-03-08       Impact factor: 4.411

4.  A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity.

Authors:  Ahmet Özdemir; Mehlika Dilek Altıntop; Belgin Sever; Hülya Karaca Gençer; Handan Açelya Kapkaç; Özlem Atlı; Merve Baysal
Journal:  Molecules       Date:  2017-11-30       Impact factor: 4.411

5.  Benzonate derivatives of acetophenone as potent α-glucosidase inhibitors: synthesis, structure-activity relationship and mechanism.

Authors:  Wen-Jia Dan; Qiang Zhang; Fan Zhang; Wei-Wei Wang; Jin-Ming Gao
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

Review 6.  Anti-Fungal Efficacy and Mechanisms of Flavonoids.

Authors:  Mohammed Saleh Al Aboody; Suresh Mickymaray
Journal:  Antibiotics (Basel)       Date:  2020-01-26

Review 7.  Galleria mellonella for the Evaluation of Antifungal Efficacy against Medically Important Fungi, a Narrative Review.

Authors:  Sana Jemel; Jacques Guillot; Kalthoum Kallel; Françoise Botterel; Eric Dannaoui
Journal:  Microorganisms       Date:  2020-03-11

8.  Synthesis and Antimicrobial Activity of Methoxy- Substituted γ-Oxa-ε-lactones Derived from Flavanones.

Authors:  Witold Gładkowski; Monika Siepka; Tomasz Janeczko; Edyta Kostrzewa-Susłow; Jarosław Popłoński; Marcelina Mazur; Barbara Żarowska; Wojciech Łaba; Gabriela Maciejewska; Czesław Wawrzeńczyk
Journal:  Molecules       Date:  2019-11-16       Impact factor: 4.411

Review 9.  Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.

Authors:  Nilce M Martinez-Rossi; Tamires A Bitencourt; Nalu T A Peres; Elza A S Lang; Eriston V Gomes; Natalia R Quaresemin; Maíra P Martins; Lucia Lopes; Antonio Rossi
Journal:  Front Microbiol       Date:  2018-05-29       Impact factor: 5.640

Review 10.  Plant Cell Cancer: May Natural Phenolic Compounds Prevent Onset and Development of Plant Cell Malignancy? A Literature Review.

Authors:  Hassan Rasouli; Mohammad Hosein Farzaei; Kamran Mansouri; Sara Mohammadzadeh; Reza Khodarahmi
Journal:  Molecules       Date:  2016-08-23       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.