Literature DB >> 27209410

Complex roles of NRAGE on tumor.

Ge Zhang1, Huandi Zhou1, Xiaoying Xue2.   

Abstract

NRAGE, also known as Dlxin-1or MAGE-D1, is a member of type II melanoma-associated antigen (MAGE) and plays an essential role in life activities, including differentiation, apoptosis, and cell cycle. Studies increasingly found that NRAGE is closely related to the tumor events, such as tumor occurrence, invasion, and metastasis. However, complex and contradictory functions of NRAGE in different circumstances are observed, suggesting that NRAGE is unique from other MAGE gene family members. This review summarizes recent findings concerning the structure and biological functions of NRAGE, which may provide a basis for a more comprehensive understanding of and further research on NRAGE.

Entities:  

Keywords:  Cell apoptosis; Cell cycle; Cell differentiation; NRAGE; Tumor

Mesh：

Substances：

Year:  2016        PMID： 27209410     DOI： 10.1007/s13277-016-5084-0

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  54 in total

1.  Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function.

Authors:  Y Masuda; A Sasaki; H Shibuya; N Ueno; K Ikeda; K Watanabe
Journal:  J Biol Chem       Date:  2000-11-17       Impact factor: 5.157

2.  A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.

Authors:  Aya Sasaki; Yoshiko Masuda; Kazuhiro Iwai; Kyoji Ikeda; Ken Watanabe
Journal:  J Biol Chem       Date:  2002-04-16       Impact factor: 5.157

3.  The Effect of NRAGE on cell cycle and apoptosis of human dental pulp cells and MDPC-23.

Authors:  Qi Wu; Shengcai Qi; Ji Ma; Fubo Chen; Jing Chen; Jing Li; Xu Zhang; Yuanzhi Xu; Qiuhui Pan; Raorao Wang
Journal:  Int J Clin Exp Med       Date:  2015-07-15

4.  MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation.

Authors:  Akihiro Mouri; Aya Sasaki; Ken Watanabe; Chiharu Sogawa; Shigeo Kitayama; Takayoshi Mamiya; Yoshiaki Miyamoto; Kiyofumi Yamada; Yukihiro Noda; Toshitaka Nabeshima
Journal:  J Neurosci       Date:  2012-03-28       Impact factor: 6.167

5.  NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death.

Authors:  Maria Grazia Di Certo; Nicoletta Corbi; Tiziana Bruno; Simona Iezzi; Francesca De Nicola; Agata Desantis; Maria Teresa Ciotti; Elisabetta Mattei; Aristide Floridi; Maurizio Fanciulli; Claudio Passananti
Journal:  J Cell Sci       Date:  2007-05-08       Impact factor: 5.285

6.  Melanoma-associated antigen family protein-D1 regulation of tumor cell migration, adhesion to endothelium, and actin structures reorganization in response to hypoxic stress.

Authors:  Wei-Gan Shen; Qing-Yu Xue; Yi-Ding Wu; Ben-Shun Hu; Jun Zhu; Yu Zhang; Qing Su
Journal:  Cell Commun Adhes       Date:  2007 Jan-Feb

7.  Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells.

Authors:  Huandi Zhou; Ge Zhang; Xiaoying Xue; Yanling Yang; Ye Yang; Xiaojing Chang; Xiaohui Ge; Zhiqing Xiao; Han Guo; Yanqiang Wang
Journal:  Tumour Biol       Date:  2016-01-07

8.  NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.

Authors:  M J M Bertrand; R S Kenchappa; D Andrieu; M Leclercq-Smekens; H N T Nguyen; B D Carter; F Muscatelli; P A Barker; O De Backer
Journal:  Cell Death Differ       Date:  2008-09-05       Impact factor: 15.828

9.  Inhibition of adenovirus-mediated human MAGE-D1 on angiogenesis in vitro and in vivo.

Authors:  Wei-Gan Shen; Qing-Yu Xue; Jun Zhu; Ben-Shun Hu; Yu Zhang; Yi-Ding Wu; Qing Su
Journal:  Mol Cell Biochem       Date:  2006-12-06       Impact factor: 3.842

10.  A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-κB activation and apoptosis in P19 cells.

Authors:  Jennifer A Rochira; Nicholas N Matluk; Tamara L Adams; Aldona A Karaczyn; Leif Oxburgh; Samuel T Hess; Joseph M Verdi
Journal:  PLoS One       Date:  2011-07-18       Impact factor: 3.240
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  6 in total

1.  NRAGE Confers Radiation Resistance in 2D and 3D Cell Culture and Poor Outcome in Patients With Esophageal Squamous Cell Carcinoma.

Authors:  Huandi Zhou; Guohui Wang; Zhiqing Xiao; Yu Yang; Zhesen Tian; Chen Gao; Xuetao Han; Wei Sun; Liubing Hou; Junling Liu; Xiaoying Xue
Journal:  Front Oncol       Date:  2022-04-01       Impact factor: 5.738

2.  NRAGE is a potential diagnostic biomarker of hepatocellular carcinoma.

Authors:  Wenshuang Zou; Junfeng Cui; Zhong Ren; Yan Leng
Journal:  Medicine (Baltimore)       Date:  2018-11       Impact factor: 1.817

3.  A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation.

Authors:  Lena Hess; Verena Moos; Arnel A Lauber; Wolfgang Reiter; Michael Schuster; Natascha Hartl; Daniel Lackner; Thorina Boenke; Anna Koren; Paloma M Guzzardo; Brigitte Gundacker; Anna Riegler; Petra Vician; Claudia Miccolo; Susanna Leiter; Mahesh B Chandrasekharan; Terezia Vcelkova; Andrea Tanzer; Jun Qi Jun; James Bradner; Gerald Brosch; Markus Hartl; Christoph Bock; Tilmann Bürckstümmer; Stefan Kubicek; Susanna Chiocca; Srividya Bhaskara; Christian Seiser
Journal:  PLoS Genet       Date:  2022-08-22       Impact factor: 6.020

Review 4.  The Pattern of Signatures in Gastric Cancer Prognosis.

Authors:  Julita Machlowska; Ryszard Maciejewski; Robert Sitarz
Journal:  Int J Mol Sci       Date:  2018-06-04       Impact factor: 5.923

5.  Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives.

Authors:  John Antonydas Gaspar; Sureshkumar Perumal Srinivasan; Poornima Sureshkumar; Michael Xavier Doss; Jürgen Hescheler; Symeon Papadopoulos; Agapios Sachinidis
Journal:  Sci Rep       Date:  2017-10-27       Impact factor: 4.379

6.  A new tool for early diagnosis of rheumatoid arthritis using combined biomarkers; synovial MAGE-1 mRNA and serum anti-CCP and RF.

Authors:  Al-Qtaitat Aiman; Mwafi Nesrin; Albtoosh Amal; Al-Dalaien Nassar
Journal:  Pan Afr Med J       Date:  2020-08-12
  6 in total

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