Hazel M Holden1, James B Thoden2, Michel Gilbert3. 1. Department of Biochemistry, University of Wisconsin, Madison, WI 53706, United States. Electronic address: hazel_holden@biochem.wisc.edu. 2. Department of Biochemistry, University of Wisconsin, Madison, WI 53706, United States. 3. Human Health Therapeutics, National Research Council Canada, Ottawa, Ontario K1A OR6, Canada.
Abstract
The N-formyltransferases, also known as transformylases, play key roles in de novo purine biosynthesis where they catalyze the transfer of formyl groups to primary amine acceptors. These enzymes require N10-formyltetrahydrofolate for activity. Due to their biological importance they have been extensively investigated for many years, and they are still serving as targets for antifolate drug design. Most of our understanding of the N-formyltransferases has been derived from these previous studies. It is now becoming increasingly apparent, however, that N-formylation also occurs on some amino sugars found on the O-antigens of pathogenic bacteria. This review focuses on recent developments in the biochemical and structural characterization of the sugar N-formyltransferases.
The N-formyltransferases, also known as transformylases, play key roles in de novo purine biosynthesis where they catalyze the transfer of formyl groups to primary n class="Chemical">amine acceptors. These enzymes require N10-formyltetrahydrofolate for activity. Due to their biological importance they have been extensively investigated for many years, and they are still serving as targets for antifolate drug design. Most of our understanding of the N-formyltransferases has been derived from these previous studies. It is now becoming increasingly apparent, however, that N-formylation also occurs on some amino sugars found on the O-antigens of pathogenic bacteria. This review focuses on recent developments in the biochemical and structural characterization of the sugar N-formyltransferases.
Authors: Bin Liu; Miao Chen; Andrei V Perepelov; Jianfeng Liu; Olga G Ovchinnikova; Dawei Zhou; Lu Feng; Antoni Rozalski; Yuriy A Knirel; Lei Wang Journal: Glycobiology Date: 2012-05-31 Impact factor: 4.313
Authors: Andrei V Perepelov; Bin Liu; Sof'ya N Senchenkova; Alexander S Shashkov; Lu Feng; Yuriy A Knirel; Lei Wang Journal: Carbohydr Res Date: 2010-05-31 Impact factor: 2.104
Authors: Olga G Ovchinnikova; Bin Liu; Dan Guo; Nina A Kocharova; Magdalena Bialczak-Kokot; Alexander S Shashkov; Lu Feng; Antoni Rozalski; Lei Wang; Yuriy A Knirel Journal: FEMS Immunol Med Microbiol Date: 2012-12
Authors: T Murata; T Iida; Y Shiomi; K Tagomori; Y Akeda; I Yanagihara; S Mushiake; F Ishiguro; T Honda Journal: J Infect Dis Date: 2001-08-29 Impact factor: 5.226
Authors: Bin Liu; Yuriy A Knirel; Lu Feng; Andrei V Perepelov; Sof'ya N Senchenkova; Quan Wang; Peter R Reeves; Lei Wang Journal: FEMS Microbiol Rev Date: 2008-04-16 Impact factor: 16.408
Authors: Elaine Scallan; Robert M Hoekstra; Frederick J Angulo; Robert V Tauxe; Marc-Alain Widdowson; Sharon L Roy; Jeffery L Jones; Patricia M Griffin Journal: Emerg Infect Dis Date: 2011-01 Impact factor: 6.883
Authors: Alexander S Riegert; Daniel P Chantigian; James B Thoden; Peter A Tipton; Hazel M Holden Journal: Biochemistry Date: 2017-07-05 Impact factor: 3.162