Literature DB >> 2720906

Computational analysis of structural and energetic consequences of DNA methylation.

F H Hausheer1, S N Rao, M P Gamcsik, P A Kollman, O M Colvin, J D Saxe, B D Nelkin, I J McLennan, G Barnett, S B Baylin.   

Abstract

The conformational and energetic consequences of cytosine methylation in eukaryotes related to transcription or formation of chromatin structure are not well understood. Structures of methylated and unmethylated DNA sequences from biologically relevant sources were studied by theoretical methods under different ionic conditions and demonstrate that cytosine methylation produces a localized pattern of steric, hydrophobic, energetic, conformational and electrostatic alterations in DNA. These findings suggest how this modification may influence protein-DNA interactions and support current hypotheses. The results reveal previously unrecognized potential effects of cytosine methylation which could critically affect normal and neoplastic cellular processes by altering transcriptional events, histone binding, chromosomal stability and cellular differentiation.

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Year:  1989        PMID： 2720906     DOI： 10.1093/carcin/10.6.1131

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  8 in total

1.  High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.

Authors:  W S el-Deiry; B D Nelkin; P Celano; R W Yen; J P Falco; S R Hamilton; S B Baylin
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

2.  Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase.

Authors:  Delshanee Kotandeniya; Daniel Murphy; Shuo Yan; Soobong Park; Uthpala Seneviratne; Joseph S Koopmeiners; Anthony Pegg; Sreenivas Kanugula; Fekadu Kassie; Natalia Tretyakova
Journal:  Biochemistry       Date:  2013-05-31       Impact factor: 3.162

3.  Density Functional Study of the Influence of C5 Cytosine Substitution in Base Pairs with Guanine.

Authors:  Adam Moser; Rebecca Guza; Natalia Tretyakova; Darrin M York
Journal:  Theor Chem Acc       Date:  2009-03-01       Impact factor: 1.702

4.  Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

Authors:  T H Bestor
Journal:  EMBO J       Date:  1992-07       Impact factor: 11.598

5.  Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA.

Authors:  Rebecca Guza; Delshanee Kotandeniya; Kristopher Murphy; Thakshila Dissanayake; Chen Lin; George Madalin Giambasu; Rahul R Lad; Filip Wojciechowski; Shantu Amin; Shana J Sturla; Robert H E Hudson; Darrin M York; Ryszard Jankowiak; Roger Jones; Natalia Y Tretyakova
Journal:  Nucleic Acids Res       Date:  2011-01-17       Impact factor: 16.971

6.  6-phenylpyrrolocytosine as a fluorescent probe to examine nucleotide flipping catalyzed by a DNA repair protein.

Authors:  Delshanee Kotandeniya; Melanie S Rogers; Jenna Fernandez; Sreenivas Kanugula; Robert H E Hudson; Freddys Rodriguez; John D Lipscomb; Natalia Tretyakova
Journal:  Biopolymers       Date:  2020-10-24       Impact factor: 2.505

Review 7.  Crop epigenetics and the molecular hardware of genotype × environment interactions.

Authors:  Graham J King
Journal:  Front Plant Sci       Date:  2015-11-06       Impact factor: 5.753

8.  Mapping structurally defined guanine oxidation products along DNA duplexes: influence of local sequence context and endogenous cytosine methylation.

Authors:  Xun Ming; Brock Matter; Matthew Song; Elizabeth Veliath; Ryan Shanley; Roger Jones; Natalia Tretyakova
Journal:  J Am Chem Soc       Date:  2014-03-10       Impact factor: 15.419
  8 in total

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