Literature DB >> 27208765

Agents of Last Resort: Polymyxin Resistance.

Keith S Kaye1, Jason M Pogue2, Thien B Tran3, Roger L Nation3, Jian Li3.   

Abstract

Polymyxin resistance is a major public health threat, as the polymyxins represent "last-line" therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Colistin; Gram-negative; Polymyxin B; Polymyxins; Resistance

Mesh：

Substances：

Year:  2016        PMID： 27208765     DOI： 10.1016/j.idc.2016.02.005

Source DB:  PubMed          Journal:  Infect Dis Clin North Am        ISSN： 0891-5520            Impact factor:   5.982


  52 in total

1.  Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane.

Authors:  Xinyu Hong; H Deborah Chen; Eduardo A Groisman
Journal:  Sci Signal       Date:  2018-05-08       Impact factor: 8.192

2.  High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii.

Authors:  Justin R Lenhard; Jürgen B Bulitta; Terry D Connell; Natalie King-Lyons; Cornelia B Landersdorfer; Soon-Ee Cheah; Visanu Thamlikitkul; Beom Soo Shin; Gauri Rao; Patricia N Holden; Thomas J Walsh; Alan Forrest; Roger L Nation; Jian Li; Brian T Tsuji
Journal:  J Antimicrob Chemother       Date:  2016-09-15       Impact factor: 5.790

3.  A short synthetic peptide, based on LyeTx I from Lycosa erythrognatha venom, shows potential to treat pneumonia caused by carbapenem-resistant Acinetobacter baumannii without detectable resistance.

Authors:  William Gustavo Lima; Júlio César Moreira Brito; Maria Elena de Lima; Amanda Cristina Silva Tardelli Pizarro; Maria Auxiliadora Martins de Mello Vianna; Magna Cristina de Paiva; Débora Cristina Sampaio de Assis; Valbert Nascimento Cardoso; Simone Odília Antunes Fernandes
Journal:  J Antibiot (Tokyo)       Date:  2021-05-10       Impact factor: 2.649

4.  Occurrence of blaKPC-2, blaCTX-M, and mcr-1 in Enterobacteriaceae from Well Water in Rural China.

Authors:  Pan Sun; Zhenwang Bi; Maud Nilsson; Beiwen Zheng; Björn Berglund; Cecilia Stålsby Lundborg; Stefan Börjesson; Xuewen Li; Baoli Chen; Hong Yin; Lennart E Nilsson
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

5.  Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models.

Authors:  Cornelia B Landersdorfer; Jiping Wang; Veronika Wirth; Ke Chen; Keith S Kaye; Brian T Tsuji; Jian Li; Roger L Nation
Journal:  J Antimicrob Chemother       Date:  2018-02-01       Impact factor: 5.790

6.  A Model for Transposition of the Colistin Resistance Gene mcr-1 by ISApl1.

Authors:  Erik Snesrud; Susu He; Michael Chandler; John P Dekker; Alison B Hickman; Patrick McGann; Fred Dyda
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

7.  Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.

Authors:  Pamela Brown; Omar Abdulle; Steven Boakes; Esther Duperchy; Stephen Moss; Mona Simonovic; Steven Stanway; Antoinette Wilson; Michael J Dawson
Journal:  Bioorg Med Chem Lett       Date:  2020-03-30       Impact factor: 2.823

Review 8.  Polymyxin Resistance in Gram-negative Pathogens.

Authors:  Pavithra Srinivas; Kaitlyn Rivard
Journal:  Curr Infect Dis Rep       Date:  2017-09-11       Impact factor: 3.725

9.  Polymyxin-resistant, carbapenem-resistant Acinetobacter baumannii is eradicated by a triple combination of agents that lack individual activity.

Authors:  Justin R Lenhard; Visanu Thamlikitkul; Fernanda P Silveira; Samira M Garonzik; Xun Tao; Alan Forrest; Beom Soo Shin; Keith S Kaye; Jürgen B Bulitta; Roger L Nation; Jian Li; Brian T Tsuji
Journal:  J Antimicrob Chemother       Date:  2017-05-01       Impact factor: 5.790

Review 10.  Rescuing the Last-Line Polymyxins: Achievements and Challenges.

Authors:  Sue C Nang; Mohammad A K Azad; Tony Velkov; Qi Tony Zhou; Jian Li
Journal:  Pharmacol Rev       Date:  2021-04       Impact factor: 25.468
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