Jessica L Harding1, Jonathan E Shaw2, Anna Peeters3, Susan Davidson4, Dianna J Magliano2. 1. Department of Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia jessica.harding@bakeridi.edu.au. 2. Department of Clinical Diabetes and Epidemiology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. 3. School of Health and Social Development, Faculty of Health, Deakin University, Burwood, Australia. 4. Diabetes Australia, Canberra, Australia.
Abstract
OBJECTIVE: To analyze changes by age-group in all-cause and cause-specific mortality rates from 2000-2011 in people with diabetes. RESEARCH DESIGN AND METHODS: A total of 1,189,079 (7.3% with type 1 diabetes) Australians with diabetes registered on the National Diabetes Service Scheme between 2000 and 2011 were linked to the National Death Index. Mortality rates in the total population were age standardized to the 2001 Australian population. Mortality rates were calculated for the following age-groups: 0 to <40 years, ≥ 40 to <60 years, and ≥60 to ≤85 years. Annual mortality rates were fitted using a Poisson regression model including calendar year as a covariate and age and sex where appropriate, with Ptrend reported. RESULTS: For type 1 diabetes, all-cause, cardiovascular disease (CVD), and diabetes age-standardized mortality rates (ASMRs) decreased each year by 0.61, 0.35, and 0.14 per 1,000 person-years (PY), respectively, between 2000 and 2011, Ptrend < 0.05, while cancer mortality remained unchanged. By age, significant decreases in all-cause, CVD, and diabetes mortality rates were observed in all age-groups, excluding diabetes mortality in age-group 0-40 years. For type 2 diabetes, all-cause, CVD, and diabetes ASMRs decreased per year by 0.18, 0.15, and 0.03 per 1,000 PY, respectively, Ptrend < 0.001, while cancer remained unchanged. By age, these decreases were observed in all age-groups, excluding 0-40 years, where significant increases in all-cause and cancer mortality were noted and no change was seen for CVD and diabetes mortality. CONCLUSIONS: All-cause, CVD, and diabetes ASMRs in type 1 and type 2 diabetes decreased between 2000 and 2011, while cancer ASMRs remained unchanged. However, younger populations are not benefiting from the same improvements as older populations. In addition, the absence of a decline in cancer mortality warrants urgent attention.
OBJECTIVE: To analyze changes by age-group in all-cause and cause-specific mortality rates from 2000-2011 in people with diabetes. RESEARCH DESIGN AND METHODS: A total of 1,189,079 (7.3% with type 1 diabetes) Australians with diabetes registered on the National Diabetes Service Scheme between 2000 and 2011 were linked to the National Death Index. Mortality rates in the total population were age standardized to the 2001 Australian population. Mortality rates were calculated for the following age-groups: 0 to <40 years, ≥ 40 to <60 years, and ≥60 to ≤85 years. Annual mortality rates were fitted using a Poisson regression model including calendar year as a covariate and age and sex where appropriate, with Ptrend reported. RESULTS: For type 1 diabetes, all-cause, cardiovascular disease (CVD), and diabetes age-standardized mortality rates (ASMRs) decreased each year by 0.61, 0.35, and 0.14 per 1,000 person-years (PY), respectively, between 2000 and 2011, Ptrend < 0.05, while cancer mortality remained unchanged. By age, significant decreases in all-cause, CVD, and diabetes mortality rates were observed in all age-groups, excluding diabetes mortality in age-group 0-40 years. For type 2 diabetes, all-cause, CVD, and diabetes ASMRs decreased per year by 0.18, 0.15, and 0.03 per 1,000 PY, respectively, Ptrend < 0.001, while cancer remained unchanged. By age, these decreases were observed in all age-groups, excluding 0-40 years, where significant increases in all-cause and cancer mortality were noted and no change was seen for CVD and diabetes mortality. CONCLUSIONS: All-cause, CVD, and diabetes ASMRs in type 1 and type 2 diabetes decreased between 2000 and 2011, while cancer ASMRs remained unchanged. However, younger populations are not benefiting from the same improvements as older populations. In addition, the absence of a decline in cancer mortality warrants urgent attention.
Authors: Jessica L Harding; Meda E Pavkov; Dianna J Magliano; Jonathan E Shaw; Edward W Gregg Journal: Diabetologia Date: 2018-08-31 Impact factor: 10.122
Authors: Yiling J Cheng; Giuseppina Imperatore; Linda S Geiss; Sharon H Saydah; Ann L Albright; Mohammed K Ali; Edward W Gregg Journal: Diabetes Care Date: 2018-08-21 Impact factor: 19.112
Authors: Julie A Lovshin; Geneviève Boulet; Yuliya Lytvyn; Leif E Lovblom; Petter Bjornstad; Mohammed A Farooqi; Vesta Lai; Leslie Cham; Josephine Tse; Andrej Orszag; Daniel Scarr; Alanna Weisman; Hillary A Keenan; Michael H Brent; Narinder Paul; Vera Bril; Bruce A Perkins; David Zi Cherney Journal: JCI Insight Date: 2018-01-11
Authors: Lee Ling Lim; Eric S H Lau; Alice P S Kong; Melanie J Davies; Naomi S Levitt; Björn Eliasson; Carlos A Aguilar-Salinas; Guang Ning; Yutaka Seino; Wing Yee So; Margaret McGill; Graham D Ogle; Trevor J Orchard; Philip Clarke; Rury R Holman; Edward W Gregg; Juan José Gagliardino; Juliana C N Chan Journal: Diabetes Care Date: 2018-06 Impact factor: 19.112
Authors: Jessica L Harding; Linda J Andes; Edward W Gregg; Yiling J Cheng; Hannah K Weir; Kai M Bullard; Nilka Ríos Burrows; Giuseppina Imperatore Journal: Diabetologia Date: 2019-09-12 Impact factor: 10.122
Authors: Rachel G Miller; Hemant D Mahajan; Tina Costacou; Akira Sekikawa; Stewart J Anderson; Trevor J Orchard Journal: Diabetes Care Date: 2016-09-21 Impact factor: 19.112
Authors: Liane J Tinsley; Varant Kupelian; Stephanie A D'Eon; David Pober; Jennifer K Sun; George L King; Hillary A Keenan Journal: J Clin Endocrinol Metab Date: 2017-10-01 Impact factor: 5.958