Abigail Livny1, Ramit Ravona-Springer2, Anthony Heymann3, Rachel Priess4, Tammar Kushnir5, Galia Tsarfaty5, Leeron Rabinov6, Reut Moran6, Hadass Hoffman7, Itzik Cooper8, Lior Greenbaum7, Jeremy Silverman9, Mary Sano10, Sterling C Johnson11, Barbara B Bendlin11, Michal Schnaider Beeri8. 1. Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel abigail.livnyezer@gmail.com. 2. Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel Memory Clinic, Sheba Medical Center, Tel HaShomer, Israel. 3. Maccabi Healthcare Services, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 4. Maccabi Healthcare Services, Tel Aviv, Israel. 5. Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 6. Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel. 7. Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel. 8. Josef Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel School of Psychology, Interdisciplinary Center Herzliya, Herzliya, Israel. 9. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY James J. Peters Veterans Affairs Medical Center, Bronx, NY. 10. School of Psychology, Interdisciplinary Center Herzliya, Herzliya, Israel. 11. William S. Middleton Memorial Veterans Hospital, Madison, WI Wisconsin Alzheimer's Disease Research Center, Madison, WI.
Abstract
OBJECTIVE: We assessed whether the apolipoprotein ε4 (APOE4) genotype affects the relationship of variability in long-term glycemic control (measured by HbA1c SD of multiple measurements) with white matter hyperintensities (WMHs) in elderly patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: WMH volume was generated from structural T1 and fluid-attenuated inversion recovery MRI in each subject. The analysis included 124 subjects; 27 (21.8%) had one or more APOE4 alleles. RESULTS: HbA1c variability was associated with significantly higher WMH in APOE4 carriers (r = 0.47, P = 0.03), controlling for age, sex, mean HbA1c, number of follow-up years, and a composite of cardiovascular risk factors, but not in noncarriers (r = -0.04, P = 0.71; P for interaction = 0.050). CONCLUSIONS: The results suggest that the APOE4 genotype affects the relationship of long-term glycemic control with WMH load so that APOE4 carriers may be more vulnerable to the insults of poor control.
OBJECTIVE: We assessed whether the apolipoprotein ε4 (APOE4) genotype affects the relationship of variability in long-term glycemic control (measured by HbA1c SD of multiple measurements) with white matter hyperintensities (WMHs) in elderly patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: WMH volume was generated from structural T1 and fluid-attenuated inversion recovery MRI in each subject. The analysis included 124 subjects; 27 (21.8%) had one or more APOE4 alleles. RESULTS: HbA1c variability was associated with significantly higher WMH in APOE4 carriers (r = 0.47, P = 0.03), controlling for age, sex, mean HbA1c, number of follow-up years, and a composite of cardiovascular risk factors, but not in noncarriers (r = -0.04, P = 0.71; P for interaction = 0.050). CONCLUSIONS: The results suggest that the APOE4 genotype affects the relationship of long-term glycemic control with WMH load so that APOE4 carriers may be more vulnerable to the insults of poor control.
Authors: Jeroen de Bresser; Audrey M Tiehuis; Esther van den Berg; Yael D Reijmer; Cynthia Jongen; L Jaap Kappelle; Willem P Mali; Max A Viergever; Geert Jan Biessels Journal: Diabetes Care Date: 2010-03-18 Impact factor: 19.112
Authors: A Sugawara; K Kawai; S Motohashi; K Saito; S Kodama; Y Yachi; R Hirasawa; H Shimano; K Yamazaki; H Sone Journal: Diabetologia Date: 2012-05-12 Impact factor: 10.122
Authors: C Jongen; J van der Grond; L J Kappelle; G J Biessels; M A Viergever; J P W Pluim Journal: Diabetologia Date: 2007-05-11 Impact factor: 10.122
Authors: Junghyun H Lee; Yera Choi; Chansoo Jun; Young Sun Hong; Han Byul Cho; Jieun E Kim; In Kyoon Lyoo Journal: Endocrinol Metab (Seoul) Date: 2014-06
Authors: Minjie Wu; Omalara Fatukasi; Shaolin Yang; Jeffery Alger; Peter B Barker; Hoby Hetherington; Tae Kim; Andrew Levine; Eileen Martin; Cynthia A Munro; Todd Parrish; Ann Ragin; Ned Sacktor; Eric Seaberg; James T Becker Journal: AIDS Date: 2018-08-24 Impact factor: 4.177
Authors: Todd R Sponholtz; Edwin R van den Heuvel; Vanessa Xanthakis; Ramachandran S Vasan Journal: J Am Heart Assoc Date: 2019-04-02 Impact factor: 5.501
Authors: E Alkan; T P Taporoski; A Sterr; M von Schantz; H Vallada; J E Krieger; A C Pereira; R Alvim; A R V R Horimoto; S Pompéia; A B Negrão; S L H Evans Journal: Sci Rep Date: 2019-03-13 Impact factor: 4.379