| Literature DB >> 27208176 |
Zhenyou Zou1, Mengjie Ni2, Jing Zhang3, Yongfeng Chen2, Hongyu Ma4, Shihan Qian2, Longhua Tang2, Jiamei Tang2, Hailun Yao2, Chengbin Zhao2, Xiongwen Lu2, Hongyang Sun2, Jue Qian2, Xiaoting Mao2, Xulin Lu2, Qun Liu2, Juping Zen2, Hanbing Wu2, Zhaosheng Bao2, Shudan Lin2, Hongyu Sheng2, Yunlong Li2, Yong Liang2, Zhiqiang Chen2, Dan Zong2.
Abstract
Cell proliferation was inhibited following forced over-expression of miR-30a in the ovary cancer cell line A2780DX5 and the gastric cancer cell line SGC7901R. Interestingly, miR-30a targets the DNA replication protein RPA1, hinders the replication of DNA and induces DNA fragmentation. Furthermore, ataxia telangiectasia mutated (ATM) and checkpoint kinase 2 (CHK2) were phosphorylated after DNA damage, which induced p53 expression, thus triggering the S-phase checkpoint, arresting cell cycle progression and ultimately initiating cancer cell apoptosis. Therefore, forced miR-30a over-expression in cancer cells can be a potential way to inhibit tumour development.Entities:
Keywords: DNA replication; RPA1; S-phase checkpoint; cell cycle arrest; miR-30a
Mesh：
Substances：
Year: 2016 PMID： 27208176 DOI： 10.1042/BCJ20160177
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857