Literature DB >> 2720787

The genes and transcripts of an antigen gene expression site from T. brucei.

E Pays1, P Tebabi, A Pays, H Coquelet, P Revelard, D Salmon, M Steinert.   

Abstract

The AnTat 1.3A antigen gene expression site of T. brucei was cloned from genomic libraries of the 200 kb expressor chromosome. In addition to the antigen gene, it contains seven putative coding regions (ESAGs, for expression site-associated genes), as well as a RIME retroposon. The polypeptide encoded by ESAG 4 shows homology to yeast adenylate cyclase, and possesses structural features of a transmembrane protein. The expression site is transcribed by a pol l-like polymerase in the parasite bloodstream form only, but sequences similar to ESAGs 5, 4, and 2 are also transcribed constitutively elsewhere, by a polymerase sensitive to alpha-amanitin. Ultraviolet irradiation, which seems to block RNA processing, allows the tentative mapping of a transcription promoter about 45 kb upstream of the antigen gene.

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Year:  1989        PMID： 2720787     DOI： 10.1016/0092-8674(89)90798-8

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  79 in total

1.  Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes.

Authors:  D J LaCount; N M El-Sayed; S Kaul; D Wanless; C M Turner; J E Donelson
Journal:  Nucleic Acids Res       Date:  2001-05-15       Impact factor: 16.971

2.  A proposed mechanism for promoter-associated DNA rearrangement events at a variant surface glycoprotein gene expression site.

Authors:  K M Gottesdiener; L Goriparthi; J P Masucci; L H Van der Ploeg
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

3.  A gene from the VSG expression site of Trypanosoma brucei encodes a protein with both leucine-rich repeats and a putative zinc finger.

Authors:  P Revelard; S Lips; E Pays
Journal:  Nucleic Acids Res       Date:  1990-12-25       Impact factor: 16.971

4.  The trypanosome leucine repeat gene in the variant surface glycoprotein expression site encodes a putative metal-binding domain and a region resembling protein-binding domains of yeast, Drosophila, and mammalian proteins.

Authors:  B L Smiley; A W Stadnyk; P J Myler; K Stuart
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

5.  Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase-thymidylate synthase (R) region of Leishmania major.

Authors:  G M Kapler; K Zhang; S M Beverley
Journal:  Nucleic Acids Res       Date:  1990-11-11       Impact factor: 16.971

6.  Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms.

Authors:  Eleanor M Barnwell; Frederick J van Deursen; Laura Jeacock; Katherine A Smith; Rick M Maizels; Alvaro Acosta-Serrano; Keith Matthews
Journal:  J Cell Sci       Date:  2010-09-07       Impact factor: 5.285

7.  A role for RAD51 and homologous recombination in Trypanosoma brucei antigenic variation.

Authors:  R McCulloch; J D Barry
Journal:  Genes Dev       Date:  1999-11-01       Impact factor: 11.361

8.  Antigenic variation in Trypanosoma brucei: a telomeric expression site for variant-specific surface glycoprotein genes with novel features.

Authors:  J C Zomerdijk; R Kieft; M Duyndam; P G Shiels; P Borst
Journal:  Nucleic Acids Res       Date:  1991-04-11       Impact factor: 16.971

9.  Characterization of VSG gene expression site promoters and promoter-associated DNA rearrangement events.

Authors:  K Gottesdiener; H M Chung; S D Brown; M G Lee; L H Van der Ploeg
Journal:  Mol Cell Biol       Date:  1991-05       Impact factor: 4.272

10.  A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei.

Authors:  P Paindavoine; S Rolin; S Van Assel; M Geuskens; J C Jauniaux; C Dinsart; G Huet; E Pays
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272
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