Elodie Setrouk1, Beatrice Hubault1, Frédérique Vankemmel2, Olivia Zambrowski1, Pierre Nazeyrollas3, Brigitte Delemer4,3, Vincent Durlach3, Alain Ducasse1, Carl Arndt5. 1. Service d'Ophtalmologie, Pôle tête et cou, Hôpital Robert Debré, Centre Hospitalo-Universitaire, 51092, Reims, France. 2. Centre d'évaluation et de traitement de la Douleur, Pôle d'Anesthésie-Réanimation, Centre Hospitalo-Universitaire, 51092, Reims, France. 3. Pôle Thoracique / Cardiaque / Vasculaire, Centre Hospitalo-Universitaire, 51092, Reims, France. 4. Service d'Endocrinologie, Maladies Métaboliques et de Médecine Interne, Pôle Digestif / Urologie / Néphrologie / Endocrinologie (D.U.N.E.), Centre Hospitalo-Universitaire, 51092, Reims, France. 5. Service d'Ophtalmologie, Pôle tête et cou, Hôpital Robert Debré, Centre Hospitalo-Universitaire, 51092, Reims, France. carndt@chu-reims.fr.
Abstract
BACKGROUND: This present retrospective case control study was designed to evaluate circadian disturbance in patients with chronic idiopathic central serous chorioretinopathy (ICSC). METHODS: Between January 1st, 2012, and November 30th, 2014, 29 consecutive patients with chronic ICSC examined in a referral setting were compared with a gender-matched and age-matched control group of 29 patients. A history of pharmacologic medication (including corticosteroid treatment), sleep disturbance, irregular working hours, cardiovascular risk factors, and depressive anxiety disorders was noted. RESULTS: The median age of the patients was 52, and in the control subjects it was 50. The male-female ratio for both groups was 4.8:1. Patients with chronic ISCS were more likely to be exposed to irregular working hours (p < 0.01, OR 9.3 [2.29-37.6]) and to present with overweight than the control subjects (p = 0.016). No significant differences were found for sleeping disturbances, pharmacological medication, cardiovascular risk factors, or depressive anxiety disorders. CONCLUSIONS: In this preliminary study, the exposition of irregular working hours as a risk factor for chronic ICSC was identified, which had not been previously reported. If further studies confirm these findings, then employment with regular working hours could be recommended for chronic ICSC patients.
BACKGROUND: This present retrospective case control study was designed to evaluate circadian disturbance in patients with chronic idiopathic central serous chorioretinopathy (ICSC). METHODS: Between January 1st, 2012, and November 30th, 2014, 29 consecutive patients with chronic ICSC examined in a referral setting were compared with a gender-matched and age-matched control group of 29 patients. A history of pharmacologic medication (including corticosteroid treatment), sleep disturbance, irregular working hours, cardiovascular risk factors, and depressive anxiety disorders was noted. RESULTS: The median age of the patients was 52, and in the control subjects it was 50. The male-female ratio for both groups was 4.8:1. Patients with chronic ISCS were more likely to be exposed to irregular working hours (p < 0.01, OR 9.3 [2.29-37.6]) and to present with overweight than the control subjects (p = 0.016). No significant differences were found for sleeping disturbances, pharmacological medication, cardiovascular risk factors, or depressive anxiety disorders. CONCLUSIONS: In this preliminary study, the exposition of irregular working hours as a risk factor for chronic ICSC was identified, which had not been previously reported. If further studies confirm these findings, then employment with regular working hours could be recommended for chronic ICSC patients.
Entities:
Keywords:
Central serous chorioretinopathy; Circadian; Overweight; Working hours
Authors: H Skarlandtová; M Bičíková; P Neužil; M Mlček; V Hrachovina; T Svoboda; E Medová; J Kudlička; A Dohnalová; S Havránek; H Kazihnítková; L Máčová; E Vařejková; O Kittnar Journal: Physiol Res Date: 2011-12-20 Impact factor: 1.881
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