Jacques Fourquet1, Marie-Pierre Sunyach2, Florent Vilotte3, Cécile Le Péchoux4, Dominique Ranchère-Vince5, Sylvie Bonvalot6, Jean-Michel Coindre7, Philippe Terrier8, Pierre Meeus9, Sylvie Helfre10, Etienne Martin11, Guillaume Vogin12, Julian Biau13, William Kao14, Georges Noel15, Anne Ducassou16, Carmen Llacer-Moscardo17, Eberhard Stoeckle18, Nicolas Penel19, Paul Sargos3. 1. Department of Radiation Oncology, Centre Oscar Lambret, Lille, France. Electronic address: jacfourquet@gmail.com. 2. Department of Radiation Oncology, Centre Léon Bérard, Lyon, France. 3. Department of Radiation Oncology, Institut Bergonié, Bordeaux, France. 4. Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France. 5. Department of Biopathology, Centre Léon Bérard, Lyon, France. 6. Department of Surgery, Institut Gustave Roussy, Villejuif, France; Department of Surgery, Institut Curie, Paris, France. 7. University of Bordeaux, INSERM U916, Department of Biopathology, Institut Bergonié, Bordeaux, France. 8. Department of Pathology, Institut Gustave Roussy, Villejuif, France. 9. Department of Surgery, Centre Léon Bérard, Lyon, France. 10. Department of Radiation Oncology, Institut Curie, Paris, France. 11. Department of Radiation Oncology, Centre Georges-François Leclerc, Dijon, France. 12. Department of Radiation Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France. 13. Department of Radiation Oncology, Centre Jean Perrin, Clermont-Ferrand, France. 14. Department of Radiation Oncology, Centre François Baclesse, Caen, France. 15. Department of Radiation Oncology, Centre Paul Strauss, Strasbourg, France. 16. Department of Radiation Oncology, Institut Claudius Regaud, IUCT-Oncopole, Toulouse, France. 17. Department of Radiation Oncology, Institut du Cancer de Montpellier, France. 18. Department of Surgery, Institut Bergonié, Bordeaux, France. 19. Department of Medical Oncology, Centre Oscar Lambret, Lille, France.
Abstract
PURPOSE: The aim of this study was to evaluate the impact of the time interval (TI) between surgery and adjuvant radiotherapy (RT) in soft tissue sarcoma (STS). METHODS AND MATERIALS: Data from 1131 patients treated between 1990 and 2014 were retrospectively reviewed. Inclusion criteria were: limb or superficial trunk wall STS (R0 or R1 resection) and adjuvant RT. The impact of TI on 10-year local relapse-free survival (LRFS) and 10-year overall survival (OS) was analyzed using a Log-rank test and then Cox Model. RESULTS: The median TI was 82days (range, 18-346). With a median follow-up of 235months (range, 2-296months), the 10-year LRFS was 57.5% (±2%) and the 10-year OS was 64.2% (±2%). With a TI of 19-39days, 40-79days, 80-119days, and ⩾120days, 10-year LRFSs were 65.3%, 55.5%, 56.9% and 61.2% (p=0.465), and 10-year OSs were 72.8%, 60.7%, 66.4% and 62.1% (p=0.347), respectively. After adjustment for the factors significantly (p⩽0.05) associated with LRFS and OS, TI did not alter LRFS (p=0.182) either OS (p=0.335). CONCLUSIONS: In this retrospective STS database study, the TI between surgery and start of adjuvant RT did not seem to affect outcomes.
PURPOSE: The aim of this study was to evaluate the impact of the time interval (TI) between surgery and adjuvant radiotherapy (RT) in soft tissue sarcoma (STS). METHODS AND MATERIALS: Data from 1131 patients treated between 1990 and 2014 were retrospectively reviewed. Inclusion criteria were: limb or superficial trunk wall STS (R0 or R1 resection) and adjuvant RT. The impact of TI on 10-year local relapse-free survival (LRFS) and 10-year overall survival (OS) was analyzed using a Log-rank test and then Cox Model. RESULTS: The median TI was 82days (range, 18-346). With a median follow-up of 235months (range, 2-296months), the 10-year LRFS was 57.5% (±2%) and the 10-year OS was 64.2% (±2%). With a TI of 19-39days, 40-79days, 80-119days, and ⩾120days, 10-year LRFSs were 65.3%, 55.5%, 56.9% and 61.2% (p=0.465), and 10-year OSs were 72.8%, 60.7%, 66.4% and 62.1% (p=0.347), respectively. After adjustment for the factors significantly (p⩽0.05) associated with LRFS and OS, TI did not alter LRFS (p=0.182) either OS (p=0.335). CONCLUSIONS: In this retrospective STS database study, the TI between surgery and start of adjuvant RT did not seem to affect outcomes.