Literature DB >> 27206803

Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe.

Benoit Driesschaert1,2, Andrey A Bobko3,4, Valery V Khramtsov5,6, Jay L Zweier7.   

Abstract

Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M-1 s-1 which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.

Entities:  

Keywords:  EPR; Oxygen; ROS; Superoxide; Trityl

Mesh：

Substances：

Year:  2016        PMID： 27206803      PMCID： PMC5116421          DOI： 10.1007/s12013-016-0732-y

Source DB:  PubMed          Journal:  Cell Biochem Biophys        ISSN： 1085-9195            Impact factor:   2.194


  10 in total

1.  Toward stable electron paramagnetic resonance oximetry probes: synthesis, characterization, and metabolic evaluation of new ester derivatives of a tris-(para-carboxyltetrathiaaryl)methyl (TAM) radical.

Authors:  Christophe Decroos; Véronique Balland; Jean-Luc Boucher; Gildas Bertho; Yun Xu-Li; Daniel Mansuy
Journal:  Chem Res Toxicol       Date:  2013-09-26       Impact factor: 3.739

2.  Unprecedented ipso aromatic nucleophilic substitution upon oxidative decarboxylation of tris(p-carboxyltetrathiaaryl)methyl (TAM) radicals: a new access to diversely substituted TAM radicals.

Authors:  Christophe Decroos; Thierry Prangé; Daniel Mansuy; Jean-Luc Boucher; Yun Li
Journal:  Chem Commun (Camb)       Date:  2011-03-16       Impact factor: 6.222

3.  Fourier transform EPR spectroscopy of trityl radicals for multifunctional assessment of chemical microenvironment.

Authors:  Andrey A Bobko; Ilirian Dhimitruka; Jay L Zweier; Valery V Khramtsov
Journal:  Angew Chem Int Ed Engl       Date:  2014-02-02       Impact factor: 15.336

Review 4.  Nitric oxide and peroxynitrite in health and disease.

Authors:  Pál Pacher; Joseph S Beckman; Lucas Liaudet
Journal:  Physiol Rev       Date:  2007-01       Impact factor: 37.312

5.  Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe.

Authors:  Yangping Liu; Yuguang Song; Francesco De Pascali; Xiaoping Liu; Frederick A Villamena; Jay L Zweier
Journal:  Free Radic Biol Med       Date:  2012-09-20       Impact factor: 7.376

6.  EPR oxygen images predict tumor control by a 50% tumor control radiation dose.

Authors:  Martyna Elas; Jessica M Magwood; Brandi Butler; Chanel Li; Rona Wardak; Rebekah DeVries; Eugene D Barth; Boris Epel; Samuel Rubinstein; Charles A Pelizzari; Ralph R Weichselbaum; Howard J Halpern
Journal:  Cancer Res       Date:  2013-07-16       Impact factor: 12.701

7.  Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry.

Authors:  Vijay Kumar Kutala; Narasimham L Parinandi; Jay L Zweier; Periannan Kuppusamy
Journal:  Arch Biochem Biophys       Date:  2004-04-01       Impact factor: 4.013

8.  Phosphonated trityl probes for concurrent in vivo tissue oxygen and pH monitoring using electron paramagnetic resonance-based techniques.

Authors:  Ilirian Dhimitruka; Andrey A Bobko; Timothy D Eubank; Denis A Komarov; Valery V Khramtsov
Journal:  J Am Chem Soc       Date:  2013-04-05       Impact factor: 15.419

9.  Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-.

Authors:  Christophe Decroos; Yun Li; Gildas Bertho; Yves Frapart; Daniel Mansuy; Jean-Luc Boucher
Journal:  Chem Commun (Camb)       Date:  2009-01-22       Impact factor: 6.222

10.  Reactivity of superoxide anion radical with a perchlorotriphenylmethyl (trityl) radical.

Authors:  Vijay Kumar Kutala; Frederick A Villamena; Govindasamy Ilangovan; Daniel Maspoch; Nans Roques; Jaume Veciana; Concepció Rovira; Periannan Kuppusamy
Journal:  J Phys Chem B       Date:  2007-12-15       Impact factor: 2.991
  10 in total
  3 in total

1.  Triarylmethyl-based biradical as a superoxide probe.

Authors:  Martin Poncelet; Benoit Driesschaert; Andrey A Bobko; Valery V Khramtsov
Journal:  Free Radic Res       Date:  2017-09-04

2.  Synthesis, Characterization, and Application of a Highly Hydrophilic Triarylmethyl Radical for Biomedical EPR.

Authors:  Urikhan Sanzhaeva; Martin Poncelet; Oxana Tseytlin; Mark Tseytlin; Marieta Gencheva; Timothy D Eubank; Valery V Khramtsov; Benoit Driesschaert
Journal:  J Org Chem       Date:  2020-08-06       Impact factor: 4.354

3.  Large-scale synthesis of a monophosphonated tetrathiatriarylmethyl spin probe for concurrent in vivo measurement of pO2, pH and inorganic phosphate by EPR.

Authors:  Teresa D Gluth; Martin Poncelet; Stephen DeVience; Marieta Gencheva; Emily H Hoblitzell; Valery V Khramtsov; Timothy D Eubank; Benoit Driesschaert
Journal:  RSC Adv       Date:  2021-07-27       Impact factor: 4.036
  3 in total

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