| Literature DB >> 27203373 |
Richard W Wong1, Maximiliano D'Angelo2.
Abstract
Suppression of a nuclear pore protein Nup358/RanBP2 is linked to mitotic cell death, but the clinical relevance of this link is unknown. In a recent issue of Cell, Vecchione et al. (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival. Treatment with vinorelbine, a microtubule-depolymerizing drug that inhibits mitosis, might be a potential treatment for these CCs.Entities:
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Year: 2016 PMID： 27203373 PMCID： PMC5421494 DOI： 10.1016/j.chembiol.2016.05.004
Source DB: PubMed Journal: Cell Chem Biol ISSN： 2451-9448 Impact factor: 8.116