Literature DB >> 27203173

Defective Autophagy Initiates Malignant Transformation.

Lorenzo Galluzzi1, José Manuel Bravo-San Pedro2, Guido Kroemer3.   

Abstract

In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  U2AF1(S34F); alternative splicing; autophagic flux; mutational rate; myelodysplastic syndrome; regulated cell death

Mesh：

Substances：

Year:  2016        PMID： 27203173     DOI： 10.1016/j.molcel.2016.05.001

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  12 in total

Review 1.  Therapeutic modulation of autophagy: which disease comes first?

Authors:  Maria Chiara Maiuri; Guido Kroemer
Journal:  Cell Death Differ       Date:  2019-02-06       Impact factor: 15.828

2.  Autophagy coupled to translation is required for long-term memory.

Authors:  Kiran Pandey; Xiao-Wen Yu; Adam Steinmetz; Cristina M Alberini
Journal:  Autophagy       Date:  2020-06-17       Impact factor: 16.016

3.  Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo.

Authors:  Lan Zhang; Leilei Fu; Shouyue Zhang; Jin Zhang; Yuqian Zhao; Yaxin Zheng; Gu He; Shengyong Yang; Liang Ouyang; Bo Liu
Journal:  Chem Sci       Date:  2017-01-09       Impact factor: 9.825

4.  Inhibitor of growth protein 4 interacts with Beclin 1 and represses autophagy.

Authors:  Valentina Sica; José Manuel Bravo-San Pedro; Guo Chen; Guillermo Mariño; Sylvie Lachkar; Valentina Izzo; Maria Chiara Maiuri; Mireia Niso-Santano; Guido Kroemer
Journal:  Oncotarget       Date:  2017-07-06

Review 5.  Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences.

Authors:  Mara Cirone; Maria Saveria Gilardini Montani; Marisa Granato; Alessia Garufi; Alberto Faggioni; Gabriella D'Orazi
Journal:  J Exp Clin Cancer Res       Date:  2019-06-14

6.  Alterations of miRNAs and Their Potential Roles in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells.

Authors:  Shiyan Gu; Donglei Sun; Xinyang Li; Zunzhen Zhang
Journal:  Genes (Basel)       Date:  2017-10-03       Impact factor: 4.096

7.  cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53.

Authors:  Seham Skah; Nina Richartz; Eva Duthil; Karin M Gilljam; Christian Bindesbøll; Elin Hallan Naderi; Agnete B Eriksen; Ellen Ruud; Marta M Dirdal; Anne Simonsen; Heidi Kiil Blomhoff
Journal:  Oncotarget       Date:  2018-07-13

8.  Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells.

Authors:  Félice A Janser; Olivia Adams; Vanessa Bütler; Anna M Schläfli; Bastian Dislich; Christian A Seiler; Dino Kröll; Rupert Langer; Mario P Tschan
Journal:  Int J Mol Sci       Date:  2018-10-08       Impact factor: 5.923

Review 9.  EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis.

Authors:  Mara Cirone
Journal:  Viruses       Date:  2018-10-31       Impact factor: 5.048

10.  PPARγ2 functions as a tumor suppressor in a translational mouse model of human prostate cancer.

Authors:  Fu-Lu Dong; Dong-Mei Liu; Ting-Ting Lu; Feng Li; Chong Zhang; Qun E; Yong-Hui Zhang
Journal:  Asian J Androl       Date:  2022 Jan-Feb       Impact factor: 3.285
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