Literature DB >> 2720305

Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine-induced excitation of mammalian motor nerve endings.

E M Silinsky1, C Solsona, J K Hirsh.   

Abstract

Pertussis toxin (PTX), which blocks certain classes of guanine nucleotide binding proteins (G proteins), consistently blocked the inhibitory effects of adenosine (100 microM-250 microM) on quantal acetylcholine (ACh) secretion in rat phrenic nerve hemidiaphragm preparations. PTX pretreatment also highlighted long-lasting increases in evoked ACh release elicited by adenosine. The results suggest that specific G proteins are involved in mediating the inhibitory effects of adenosine at motor nerve endings.

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Year:  1989        PMID： 2720305      PMCID： PMC1854458          DOI： 10.1111/j.1476-5381.1989.tb11918.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  A role for Ni in the hormonal stimulation of adenylate cyclase.

Authors:  R A Cerione; C Staniszewski; M G Caron; R J Lefkowitz; J Codina; L Birnbaumer
Journal:  Nature       Date:  1985 Nov 21-27       Impact factor: 49.962

Review 2.  How does adenosine inhibit transmitter release?

Authors:  B B Fredholm; T V Dunwiddie
Journal:  Trends Pharmacol Sci       Date:  1988-04       Impact factor: 14.819

3.  A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins.

Authors:  T Katada; K Kusakabe; M Oinuma; M Ui
Journal:  J Biol Chem       Date:  1987-09-05       Impact factor: 5.157

4.  Pertussis toxin reverses adenosine inhibition of neuronal glutamate release.

Authors:  A C Dolphin; S A Prestwich
Journal:  Nature       Date:  1985 Jul 11-17       Impact factor: 49.962

5.  Pertussis toxin blocks the inhibitory effect of adenosine on rat cerebral cortical neurons.

Authors:  M H O'Regan; J W Phillis
Journal:  Brain Res       Date:  1987-12-15       Impact factor: 3.252

6.  The origin of the post-tetanic hyperpolarization of mammalian motor nerve terminals.

Authors:  P W Gage; J I Hubbard
Journal:  J Physiol       Date:  1966-05       Impact factor: 5.182
  6 in total
  7 in total

Review 1.  Drugs and receptors. An overview of the current state of knowledge.

Authors:  T Kenakin
Journal:  Drugs       Date:  1990-11       Impact factor: 9.546

2.  Analysis of adenosine actions on Ca2+ currents and synaptic transmission in cultured rat hippocampal pyramidal neurones.

Authors:  K P Scholz; R J Miller
Journal:  J Physiol       Date:  1991-04       Impact factor: 5.182

3.  The role of cyclic AMP and its protein kinase in mediating acetylcholine release and the action of adenosine at frog motor nerve endings.

Authors:  J K Hirsh; E M Silinsky; C S Solsona
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

4.  Pertussis toxin does not affect the adenosine-induced inhibition of the efferent function of cardiac capsaicin-sensitive nerves.

Authors:  L Mantelli; S Amerini; A Rubino; F Ledda
Journal:  J Neural Transm Gen Sect       Date:  1993

5.  Muscarinic Ca2+ responses resistant to muscarinic antagonists at perisynaptic Schwann cells of the frog neuromuscular junction.

Authors:  R Robitaille; B S Jahromi; M P Charlton
Journal:  J Physiol       Date:  1997-10-15       Impact factor: 5.182

6.  LY 294002 inhibits adenosine receptor activation by a mechanism independent of effects on PI-3 kinase or casein kinase II.

Authors:  T J Searl; E M Silinsky
Journal:  Purinergic Signal       Date:  2005-12-03       Impact factor: 3.765

7.  Adenosine Receptors in Developing and Adult Mouse Neuromuscular Junctions and Functional Links With Other Metabotropic Receptor Pathways.

Authors:  Josep Tomàs; Neus Garcia; Maria A Lanuza; Manel M Santafé; Marta Tomàs; Laura Nadal; Erica Hurtado; Anna Simó-Ollé; Víctor Cilleros-Mañé; Laia Just-Borràs
Journal:  Front Pharmacol       Date:  2018-04-24       Impact factor: 5.810
  7 in total

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