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Literature DB >> 2719905

Long lasting respiratory depression induced by morphine-6-glucuronide?

J Hasselström¹, U Berg, A Löfgren, J Säwe.

Abstract

We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome. The plasma concentrations of the active metabolite M6G were more than 10 times those normally seen and the half-lives of M6G and morphine were prolonged.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1989 PMID： 2719905 PMCID： PMC1379732 DOI： 10.1111/j.1365-2125.1989.tb05401.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

22 in total

1. Morphine-6-glucuronide, a potent mu agonist.

Authors: G W Pasternak; R J Bodnar; J A Clark; C E Inturrisi
Journal: Life Sci Date: 1987-12-28 Impact factor: 5.037

2. Morphine-6-glucuronide has high affinity for the opioid receptor.

Authors: C B Christensen; L N Jørgensen
Journal: Pharmacol Toxicol Date: 1987-01

3. Potential analgesic contribution from morphine-6-glucuronide in CSF.

Authors: C W Hand; W P Blunnie; L P Claffey; A J McShane; H J McQuay; R A Moore
Journal: Lancet Date: 1987-11-21 Impact factor: 79.321

4. Enterohepatic circulation of morphine.

Authors: G W Hanks; P J Hoskin; G W Aherne; D Chapman; P Turner; P Poulain
Journal: Lancet Date: 1988-02-27 Impact factor: 79.321

5. Analgesic activity of morphine-6-glucuronide.

Authors: R Osborne; S Joel; D Trew; M Slevin
Journal: Lancet Date: 1988-04-09 Impact factor: 79.321

6. Spinal level analgesia after morphine overdose?

Authors: A P Fisher; M Hanna; S P Rhodes
Journal: Lancet Date: 1987-03-07 Impact factor: 79.321

7. Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position.

Authors: K Oguri; I Yamada-Mori; J Shigezane; T Hirano; H Yoshimura
Journal: Life Sci Date: 1987-09-21 Impact factor: 5.037

8. Renal failure does not impair the metabolism of morphine.

Authors: D F Woolner; D Winter; T J Frendin; E J Begg; K L Lynn; G J Wright
Journal: Br J Clin Pharmacol Date: 1986-07 Impact factor: 4.335

9. Kinetics of morphine in patients with renal failure.

Authors: J Säwe; I Odar-Cederlöf
Journal: Eur J Clin Pharmacol Date: 1987 Impact factor: 2.953

10. Extrahepatic glucuronidation of morphine in the dog.

Authors: E Jacqz; S Ward; R Johnson; S Schenker; J Gerkens; R A Branch
Journal: Drug Metab Dispos Date: 1986 Nov-Dec Impact factor: 3.922

16 in total

Review 1. The role of beta-glucuronidase in drug disposition and drug targeting in humans.

Authors: B Sperker; J T Backman; H K Kroemer
Journal: Clin Pharmacokinet Date: 1997-07 Impact factor: 6.447

2. Single-dose and steady-state kinetics of morphine and its metabolites in cancer patients--a comparison of two oral formulations.

Authors: J Hasselström; N Alexander; C Bringel; J O Svensson; J Säwe
Journal: Eur J Clin Pharmacol Date: 1991 Impact factor: 2.953

Review 3. Pharmacokinetics of opioids in liver disease.

Authors: I Tegeder; J Lötsch; G Geisslinger
Journal: Clin Pharmacokinet Date: 1999-07 Impact factor: 6.447

Review 4. Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users.

Authors: D I Quinn; A Wodak; R O Day
Journal: Clin Pharmacokinet Date: 1997-11 Impact factor: 6.447

5. The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive-care patients.

Authors: R W Milne; R L Nation; A A Somogyi; F Bochner; W M Griggs
Journal: Br J Clin Pharmacol Date: 1992-07 Impact factor: 4.335

6. Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations.

Authors: J Hasselström; J Säwe
Journal: Clin Pharmacokinet Date: 1993-04 Impact factor: 6.447

Review 10. Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors.

Authors: H K Kroemer; U Klotz
Journal: Clin Pharmacokinet Date: 1992-10 Impact factor: 6.447