Literature DB >> 27199030

Inducing Protein Degradation as a Therapeutic Strategy.

Craig M Crews1, Gunda Georg2, Shaomeng Wang2.   

Abstract

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Year:  2016        PMID： 27199030     DOI： 10.1021/acs.jmedchem.6b00735

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  4 in total

1.  Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression.

Authors:  Yangbing Li; Jiuling Yang; Angelo Aguilar; Donna McEachern; Sally Przybranowski; Liu Liu; Chao-Yie Yang; Mi Wang; Xin Han; Shaomeng Wang
Journal:  J Med Chem       Date:  2018-12-10       Impact factor: 7.446

2.  Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome.

Authors:  Yuntao Shi; Marcus J C Long; Masha M Rosenberg; Shican Li; Aimee Kobjack; Philip Lessans; Rory T Coffey; Lizbeth Hedstrom
Journal:  ACS Chem Biol       Date:  2016-10-18       Impact factor: 5.100

Review 3.  Emerging modes-of-action in drug discovery.

Authors:  Eric Valeur; Frank Narjes; Christian Ottmann; Alleyn T Plowright
Journal:  Medchemcomm       Date:  2019-06-25       Impact factor: 3.597

Review 4.  Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs.

Authors:  Mohd Muddassir; Kunjal Soni; Chetan B Sangani; Abdullah Alarifi; Mohd Afzal; Naaser A Y Abduh; Yongtao Duan; Poonam Bhadja
Journal:  RSC Adv       Date:  2020-12-24       Impact factor: 4.036
  4 in total

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