Literature DB >> 2719895

The need for reassessment of digoxin prescribing for the elderly.

L Nolan1, R Kenny, K O'Malley.   

Abstract

1. The prevalence and circumstance of digoxin prescribing was assessed in five private nursing homes. 2. Forty-one patients (21% residents) were taking digoxin. 3. Seventeen patients were in atrial fibrillation and the remainder in sinus rhythm. The ventricular rate exceeded 100 beats min-1 in eight of the 17 patients in atrial fibrillation. 4. Thirty-seven patients were prescribed 0.0625 mg digoxin daily and serum digoxin concentrations were subtherapeutic in 20 of 32 patients in whom concentrations were measured. 5. These data indicate a need for more careful review of the need for maintenance digoxin and illustrate the inappropriateness of routinely prescribing very low doses in all elderly patients.

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Year:  1989        PMID: 2719895      PMCID: PMC1379836          DOI: 10.1111/j.1365-2125.1989.tb05378.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  15 in total

1.  Prescribing patterns observed in registered nursing homes and long-stay geriatric wards.

Authors:  W R Primrose; A E Capewell; G K Simpson; R G Smith
Journal:  Age Ageing       Date:  1987-01       Impact factor: 10.668

2.  Computer analysis of epidemiologic data on effect of drugs on hospital patients.

Authors:  D Slone; L F Gaetano; L Lipworth; S Shapiro; G P Lewis; H Jick
Journal:  Public Health Rep       Date:  1969-01       Impact factor: 2.792

3.  Digitalis intoxication. A prospective clinical study with serum level correlations.

Authors:  G A Beller; T W Smith; W H Abelmann; E Haber; W B Hood
Journal:  N Engl J Med       Date:  1971-05-06       Impact factor: 91.245

4.  Discontinuation of maintenance digoxin therapy in general practice.

Authors:  S M Hull; A Mackintosh
Journal:  Lancet       Date:  1977-11-19       Impact factor: 79.321

5.  Epidemiological study of adverse drug reactions.

Authors:  L E Cluff; G Thornton; L Seidl; J Smith
Journal:  Trans Assoc Am Physicians       Date:  1965

6.  Digoxin in the elderly: pharmacokinetic consequences of old age.

Authors:  B Cusack; J Kelly; K O'Malley; J Noel; J Lavan; J Horgan
Journal:  Clin Pharmacol Ther       Date:  1979-06       Impact factor: 6.875

7.  Is maintenance digoxin necessary in patients with sinus rhythm?

Authors:  G D Johnston; D G McDevitt
Journal:  Lancet       Date:  1979-03-17       Impact factor: 79.321

8.  Digoxin prescribing in general practice 1967--77.

Authors:  H D Pedoe
Journal:  Lancet       Date:  1978-10-28       Impact factor: 79.321

9.  Is digoxin really important in treatment of compensated heart failure? A placebo-controlled crossover study in patients with sinus rhythm.

Authors:  J L Fleg; S H Gottlieb; E G Lakatta
Journal:  Am J Med       Date:  1982-08       Impact factor: 4.965

10.  Heart failure in outpatients: a randomized trial of digoxin versus placebo.

Authors:  D C Lee; R A Johnson; J B Bingham; M Leahy; R E Dinsmore; A H Goroll; J B Newell; H W Strauss; E Haber
Journal:  N Engl J Med       Date:  1982-03-25       Impact factor: 91.245

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  3 in total

1.  Drug-prescribing patterns in old age. A study of the impact of hospitalization on drug prescriptions and follow-up survey in patients 75 years and older.

Authors:  W Kruse; J Rampmaier; C Frauenrath-Volkers; D Volkert; I Wankmüller; W Micol; P Oster; G Schlierf
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

Review 2.  Digoxin toxicity in the aged. Characterising and avoiding the problem.

Authors:  A P Passmore; G D Johnston
Journal:  Drugs Aging       Date:  1991 Sep-Oct       Impact factor: 3.923

Review 3.  Adverse drug reactions. An overview of special considerations in the management of the elderly patient.

Authors:  L A Brawn; C M Castleden
Journal:  Drug Saf       Date:  1990 Nov-Dec       Impact factor: 5.606

  3 in total

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