PURPOSE: To compare the anterior lamina cribrosa (LC) surface position in patients with idiopathic intracranial hypertension (IIH), primary open-angle glaucoma (high-tension glaucoma [HTG] and normal-tension glaucoma [NTG]), and healthy controls using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). METHODS: This was a retrospective, cross-sectional observational study of 11 eyes with IIH, 20 eyes with HTG, 20 eyes with NTG, and 37 control eyes. Serial horizontal B-scans of the optic nerve head were obtained using EDI-OCT. The LC depth, defined as the distance from the Bruch membrane opening plane to the anterior LC surface, was manually measured on selected B-scans covering the central three-quarters of the optic nerve head in each eye. RESULTS: Mean LC depth in patients with IIH (325.2 ± 92.1 µm) was significantly (p<0.01) decreased compared to control subjects (387.8 ± 53.9 µm). In HTG, the mean LC depth (493.0 ± 115.2 µm) was significantly increased compared to NTG (376.6 ± 27.1 µm, p<0.05) and control subjects (332.7 ± 53.1 µm, p<0.001). The trans-LC pressure difference (TLPD) (intraocular pressure - cerebrospinal fluid pressure) was positively correlated with the LC depth (r = 0.96, p<0.001) and inversely correlated with visual field perimetric mean deviation in patients with IIH (r = -0.88, p<0.001). CONCLUSIONS: The LC is positioned anteriorly in patients with IIH and posteriorly in glaucomatous eyes compared to normal controls. The positional changes of the LC could be a result of the TLPD between the intraocular and intracranial pressure compartments.
PURPOSE: To compare the anterior lamina cribrosa (LC) surface position in patients with idiopathic intracranial hypertension (IIH), primary open-angle glaucoma (high-tension glaucoma [HTG] and normal-tension glaucoma [NTG]), and healthy controls using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). METHODS: This was a retrospective, cross-sectional observational study of 11 eyes with IIH, 20 eyes with HTG, 20 eyes with NTG, and 37 control eyes. Serial horizontal B-scans of the optic nerve head were obtained using EDI-OCT. The LC depth, defined as the distance from the Bruch membrane opening plane to the anterior LC surface, was manually measured on selected B-scans covering the central three-quarters of the optic nerve head in each eye. RESULTS: Mean LC depth in patients with IIH (325.2 ± 92.1 µm) was significantly (p&lt;0.01) decreased compared to control subjects (387.8 ± 53.9 µm). In HTG, the mean LC depth (493.0 ± 115.2 µm) was significantly increased compared to NTG (376.6 ± 27.1 µm, p&lt;0.05) and control subjects (332.7 ± 53.1 µm, p&lt;0.001). The trans-LC pressure difference (TLPD) (intraocular pressure - cerebrospinal fluid pressure) was positively correlated with the LC depth (r = 0.96, p&lt;0.001) and inversely correlated with visual field perimetric mean deviation in patients with IIH (r = -0.88, p&lt;0.001). CONCLUSIONS: The LC is positioned anteriorly in patients with IIH and posteriorly in glaucomatous eyes compared to normal controls. The positional changes of the LC could be a result of the TLPD between the intraocular and intracranial pressure compartments.
Authors: Ziyi Zhu; Susannah Waxman; Bo Wang; Jacob Wallace; Samantha E Schmitt; Elizabeth Tyler-Kabara; Hiroshi Ishikawa; Joel S Schuman; Matthew A Smith; Gadi Wollstein; Ian A Sigal Journal: Exp Eye Res Date: 2021-11-01 Impact factor: 3.467
Authors: Jordan W Swanson; Tomas S Aleman; Wen Xu; Gui-Shuang Ying; Wei Pan; Grant T Liu; Shih-Shan Lang; Gregory G Heuer; Phillip B Storm; Scott P Bartlett; William R Katowitz; Jesse A Taylor Journal: JAMA Ophthalmol Date: 2017-04-01 Impact factor: 7.389
Authors: Leonardo E Ariello; Luiz Guilherme Marchesi Mello; Sérgio Luis Gianotti Pimentel; Mário L R Monteiro Journal: Int J Retina Vitreous Date: 2022-07-22
Authors: Jr-Jiun Liou; Michelle D Drewry; Ashlinn Sweeney; Bryan N Brown; Jonathan P Vande Geest Journal: Transl Vis Sci Technol Date: 2020-07-13 Impact factor: 3.283