Literature DB >> 27198

Association of defective feedback suppressor T cell activity with autoimmunity in NZB mice.

R K Gershon, D D Eardley, K Naidorf, H Cantor.   

Abstract

A "feedback suppressor T cell" highly dependent on signals from Ly 1 T helper cells for activation is described. The signal from the Ly 1 cell binds to Fc-like receptors on macrophage membranes. The feedback suppressor cell expresses all three Ly antigens as well as the Qa 1 antigen on its surface, is very sensitive to low doses of cyclophosphamide, disappears relatively rapidly after adult thymectomy, and cannot be demonstrated in NZB mice 6 weeks or older.

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Year:  1978        PMID: 27198     DOI: 10.1002/art.1780210930

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN: 0004-3591


  3 in total

1.  Genetic and functional analyses of the primary in vitro CTL: response of NZB lymphocytes to H-2-compatible cells.

Authors:  W F Davidson; T M Chused; H C Morse
Journal:  Immunogenetics       Date:  1981-03-01       Impact factor: 2.846

2.  Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

Authors:  A Altman; A N Theofilopoulos; R Weiner; D H Katz; F J Dixon
Journal:  J Exp Med       Date:  1981-09-01       Impact factor: 14.307

3.  Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes.

Authors:  A N Theofilopoulos; R A Eisenberg; M Bourdon; J S Crowell; F J Dixon
Journal:  J Exp Med       Date:  1979-02-01       Impact factor: 14.307

  3 in total

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