Literature DB >> 27197916

Designing exercise clinical trials for older adults with cancer: Recommendations from 2015 Cancer and Aging Research Group NCI U13 Meeting.

Deepak Kilari1, Enrique Soto-Perez-de-Celis2, Supriya Gupta Mohile3, Shabbir M H Alibhai4, Carolyn J Presley5, Tanya M Wildes6, Heidi D Klepin7, Wendy Demark-Wahnefried8, Amina Jatoi9, Robert Harrison10, Elizabeth Won11, Karen M Mustian12.   

Abstract

Cancer and its treatment can lead to a myriad of adverse events and negatively impact quality of life of older cancer patients and survivors. Unmet physical activity needs vary across the cancer continuum and remain an important yet understudied area of research in this population. Exercise interventions have been shown to be effective in treating both the physical and psychological declines associated with cancer and its treatment, with a potential to improve cancer-related outcomes. Despite the current evidence, exercise is clearly underutilized due to several barriers and knowledge gaps in existing trials that include appropriate population identification, design, and outcome measures selection. The benefits of regular exercise in both the primary and secondary prevention of chronic conditions are well established in the non-cancer population. In older cancer patients and survivors, further research is needed before exercise gains widespread acceptance. The Cancer and Aging Research Group convened experts in exercise, aging and cancer to evaluate current scientific evidence and knowledge gaps in geriatric exercise oncology. This report summarizes these findings and provides future research directions. Published by Elsevier Ltd.

Entities:  

Keywords:  Cancer; Exercise; Geriatric recommendations; Older patients

Mesh:

Year:  2016        PMID: 27197916      PMCID: PMC4969104          DOI: 10.1016/j.jgo.2016.04.007

Source DB:  PubMed          Journal:  J Geriatr Oncol        ISSN: 1879-4068            Impact factor:   3.599


  49 in total

1.  Quality of life and perceived educational needs among older cancer survivors.

Authors:  Maura C Schlairet; Melissa J Benton
Journal:  J Cancer Educ       Date:  2012-03       Impact factor: 2.037

Review 2.  Nutrition and physical activity guidelines for cancer survivors.

Authors:  Cheryl L Rock; Colleen Doyle; Wendy Demark-Wahnefried; Jeffrey Meyerhardt; Kerry S Courneya; Anna L Schwartz; Elisa V Bandera; Kathryn K Hamilton; Barbara Grant; Marji McCullough; Tim Byers; Ted Gansler
Journal:  CA Cancer J Clin       Date:  2012-04-26       Impact factor: 508.702

3.  Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries.

Authors:  Supriya Gupta Mohile; Ying Xian; William Dale; Susan G Fisher; Miriam Rodin; Gary R Morrow; Alfred Neugut; William Hall
Journal:  J Natl Cancer Inst       Date:  2009-07-28       Impact factor: 13.506

4.  American College of Sports Medicine position stand. Exercise and physical activity for older adults.

Authors:  Wojtek J Chodzko-Zajko; David N Proctor; Maria A Fiatarone Singh; Christopher T Minson; Claudio R Nigg; George J Salem; James S Skinner
Journal:  Med Sci Sports Exerc       Date:  2009-07       Impact factor: 5.411

5.  Lifestyle intervention development study to improve physical function in older adults with cancer: outcomes from Project LEAD.

Authors:  Wendy Demark-Wahnefried; Elizabeth C Clipp; Miriam C Morey; Carl F Pieper; Richard Sloane; Denise Clutter Snyder; Harvey J Cohen
Journal:  J Clin Oncol       Date:  2006-07-20       Impact factor: 44.544

6.  Exercise manages fatigue during breast cancer treatment: a randomized controlled trial.

Authors:  Victoria Mock; Constantine Frangakis; Nancy E Davidson; Mary E Ropka; Mary Pickett; Barbara Poniatowski; Kerry J Stewart; Lane Cameron; Kristin Zawacki; Laura J Podewils; Gary Cohen; Ruth McCorkle
Journal:  Psychooncology       Date:  2005-06       Impact factor: 3.894

Review 7.  Exercise and cancer rehabilitation: a systematic review.

Authors:  Rosalind R Spence; Kristiann C Heesch; Wendy J Brown
Journal:  Cancer Treat Rev       Date:  2009-12-04       Impact factor: 12.111

8.  Can supervised exercise prevent treatment toxicity in patients with prostate cancer initiating androgen-deprivation therapy: a randomised controlled trial.

Authors:  Prue Cormie; Daniel A Galvão; Nigel Spry; David Joseph; Raphael Chee; Dennis R Taaffe; Suzanne K Chambers; Robert U Newton
Journal:  BJU Int       Date:  2014-07-27       Impact factor: 5.588

9.  Exercise Recommendations for Cancer-Related Fatigue, Cognitive Impairment, Sleep problems, Depression, Pain, Anxiety, and Physical Dysfunction: A Review.

Authors:  Karen M Mustian; Lisa K Sprod; Michelle Janelsins; Luke J Peppone; Supriya Mohile
Journal:  Oncol Hematol Rev       Date:  2012

10.  Six-month follow-up of patient-rated outcomes in a randomized controlled trial of exercise training during breast cancer chemotherapy.

Authors:  Kerry S Courneya; Roanne J Segal; Karen Gelmon; Robert D Reid; John R Mackey; Christine M Friedenreich; Caroline Proulx; Kirstin Lane; Aliya B Ladha; Jeffrey K Vallance; Qi Liu; Yutaka Yasui; Donald C McKenzie
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2007-12       Impact factor: 4.254

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  25 in total

1.  Engaging older patients with cancer and their caregivers as partners in cancer research.

Authors:  Nikesha J Gilmore; Beverly Canin; Mary Whitehead; Margaret Sedenquist; Lorraine Griggs; Lynn Finch; Valerie Grossman; Valerie Targia; Megan Wells; Charles Kamen; Marie Flannery; Allison Magnuson; Sandy Plumb; Spencer Obrecht; Lisa M Lowenstein; Gilberto Lopez; Jainy Anderson; Jeffrey Berenberg; Victor Vogel; James Bearden; William Dale; Supriya G Mohile
Journal:  Cancer       Date:  2019-08-16       Impact factor: 6.860

Review 2.  Arti Hurria and the progress in integrating the geriatric assessment into oncology: Young International Society of Geriatric Oncology review paper.

Authors:  Clark DuMontier; Mina S Sedrak; Wee Kheng Soo; Cindy Kenis; Grant R Williams; Kristen Haase; Magnus Harneshaug; Hira Mian; Kah Poh Loh; Siri Rostoft; William Dale; Harvey Jay Cohen
Journal:  J Geriatr Oncol       Date:  2019-08-23       Impact factor: 3.599

3.  Effects of a 12-Week Multimodal Exercise Intervention Among Older Patients with Advanced Cancer: Results from a Randomized Controlled Trial.

Authors:  Marta K Mikkelsen; Cecilia M Lund; Anders Vinther; Anders Tolver; Julia S Johansen; Inna Chen; Anne-Mette Ragle; Bo Zerahn; Lotte Engell-Noerregaard; Finn O Larsen; Susann Theile; Dorte L Nielsen; Mary Jarden
Journal:  Oncologist       Date:  2022-02-03       Impact factor: 5.837

4.  Cancer in the older adult: Implications for therapy and future research.

Authors:  Mina S Sedrak; Arti Hurria
Journal:  Cancer       Date:  2018-02-08       Impact factor: 6.860

5.  Exercise for Toxicity Management in Cancer-A Narrative Review.

Authors:  Ian R Kleckner; Richard F Dunne; Matthew Asare; Calvin Cole; Fergal Fleming; Chunkit Fung; Po-Ju Lin; Karen M Mustian
Journal:  Oncol Hematol Rev       Date:  2018-02-15

6.  Exercise therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer.

Authors:  Kate E Roberts; Kirsty Rickett; Sophie Feng; Dimitrios Vagenas; Natasha E Woodward
Journal:  Cochrane Database Syst Rev       Date:  2020-01-29

Review 7.  From Assessment to Implementation and Beyond in Cancer and Aging Research.

Authors:  Stuart M Lichtman; Harvey J Cohen; Hyman Muss; William P Tew; Beatriz Korc-Grodzicki
Journal:  J Clin Oncol       Date:  2021-05-27       Impact factor: 50.717

8.  Behavioral, psychological, and supportive care interventions in geriatric oncology: The Cancer and Aging Research Group infrastructure core.

Authors:  Rawad Elias; Kah Poh Loh; Valerie Targia; Mary Whitehead; Beverly Canin; Aminah Jatoi; Matthew Loscalzo; Supriya Mohile
Journal:  J Geriatr Oncol       Date:  2019-08-02       Impact factor: 3.599

9.  Functional trajectories before and after a new cancer diagnosis among community-dwelling older adults.

Authors:  C J Presley; Ling Han; Linda Leo-Summers; Arti Hurria; Cary P Gross; Amy J Davidoff; Heather G Allore; Thomas M Gill
Journal:  J Geriatr Oncol       Date:  2018-06-22       Impact factor: 3.599

10.  Study design and methods for the using exercise to relieve joint pain and improve AI adherence in older breast cancer survivors (REJOIN) trial.

Authors:  Shirley M Bluethmann; Cristina Truica; Heidi D Klepin; Nancy Olsen; Christopher Sciamanna; Vernon M Chinchilli; Kathryn H Schmitz
Journal:  J Geriatr Oncol       Date:  2021-05-26       Impact factor: 3.929

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