Literature DB >> 27197767

Novel bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution for Renilla luciferase.

Tianyu Jiang1, Xiaofeng Yang, Xingye Yang, Mingliang Yuan, Tianchao Zhang, Huateng Zhang, Minyong Li.   

Abstract

Two series of novel coelenterazine analogues (alkynes and triazoles) with imidazopyrazinone C-6 extended substitution have been designed and synthesized successfully for the extension of bioluminescent substrates. After extensive evaluation, some compounds display excellent bioluminescence properties compared with DeepBlueC in cellulo, thus becoming potential molecules for bioluminescence techniques.

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Year:  2016        PMID: 27197767     DOI: 10.1039/c6ob00659k

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  3 in total

1.  Synthetic Coelenterazine Derivatives and Their Application for Bioluminescence Imaging.

Authors:  Tianyu Jiang; Minyong Li
Journal:  Methods Mol Biol       Date:  2022

2.  Multiplex quadruple bioluminescent assay system.

Authors:  Genta Kamiya; Nobuo Kitada; Shojiro Maki; Sung Bae Kim
Journal:  Sci Rep       Date:  2022-10-19       Impact factor: 4.996

3.  Bioluminescent Properties of Semi-Synthetic Obelin and Aequorin Activated by Coelenterazine Analogues with Modifications of C-2, C-6, and C-8 Substituents.

Authors:  Elena V Eremeeva; Tianyu Jiang; Natalia P Malikova; Minyong Li; Eugene S Vysotski
Journal:  Int J Mol Sci       Date:  2020-07-30       Impact factor: 5.923

  3 in total

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