Literature DB >> 27196598

Drug development in IBD: from novel target identification to early clinical trials.

Silvio Danese1, Claudio Fiocchi2, Julián Panés3.   

Abstract

Keywords:  IBD; IBD CLINICAL; IBD MODELS

Mesh：

Substances：

Year:  2016        PMID： 27196598     DOI： 10.1136/gutjnl-2016-311717

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


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  11 in total

1.  Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.

Authors:  Jerome C Martin; Christie Chang; Gilles Boschetti; Ryan Ungaro; Mamta Giri; John A Grout; Kyle Gettler; Ling-Shiang Chuang; Shikha Nayar; Alexander J Greenstein; Marla Dubinsky; Laura Walker; Andrew Leader; Jay S Fine; Charles E Whitehurst; M Lamine Mbow; Subra Kugathasan; Lee A Denson; Jeffrey S Hyams; Joshua R Friedman; Prerak T Desai; Huaibin M Ko; Ilaria Laface; Guray Akturk; Eric E Schadt; Helene Salmon; Sacha Gnjatic; Adeeb H Rahman; Miriam Merad; Judy H Cho; Ephraim Kenigsberg
Journal:  Cell       Date:  2019-08-29       Impact factor: 41.582

2.  Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms.

Authors:  Andrew Leber; Raquel Hontecillas; Victoria Zoccoli-Rodriguez; Josep Bassaganya-Riera
Journal:  Inflamm Bowel Dis       Date:  2018-08-16       Impact factor: 5.325

3.  Systems pharmacology approach uncovers Ligustilide attenuates experimental colitis in mice by inhibiting PPARγ-mediated inflammation pathways.

Authors:  Yujie Huang; Yifan Zhang; Ting Wan; Yu Mei; Zihao Wang; Jincheng Xue; Yi Luo; Min Li; Shuhuan Fang; Huafeng Pan; Qi Wang; Jiansong Fang
Journal:  Cell Biol Toxicol       Date:  2020-10-31       Impact factor: 6.691

4.  Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease.

Authors:  Christopher J Tyler; Tamara Pérez-Jeldres; Erik Ehinger; Brian Capaldo; Thangaraj Karuppuchamy; Joshua D Boyer; Derek Patel; Parambir Dulai; Brigid S Boland; Joanne Lannigan; Lars Eckmann; Peter B Ernst; William J Sandborn; Samuel B Ho; Jesús Rivera-Nieves
Journal:  Inflamm Bowel Dis       Date:  2018-10-12       Impact factor: 7.290

Review 5.  The Dual Role of Neutrophils in Inflammatory Bowel Diseases.

Authors:  Odile Wéra; Patrizio Lancellotti; Cécile Oury
Journal:  J Clin Med       Date:  2016-12-17       Impact factor: 4.241

Review 6.  Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets.

Authors:  Hayandra Ferreira Nanini; Claudio Bernardazzi; Fernando Castro; Heitor Siffert Pereira de Souza
Journal:  World J Gastroenterol       Date:  2018-11-07       Impact factor: 5.742

Review 7.  Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification.

Authors:  Bjoern Titz; Raffaella M Gadaleta; Giuseppe Lo Sasso; Ashraf Elamin; Kim Ekroos; Nikolai V Ivanov; Manuel C Peitsch; Julia Hoeng
Journal:  Int J Mol Sci       Date:  2018-09-15       Impact factor: 5.923

8.  FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Ameliorates DSS-Induced Colitis Against Oxidative Stress by Activating Nrf2/HO-1 Pathway.

Authors:  Yu Mei; Zihao Wang; Yifan Zhang; Ting Wan; Jincheng Xue; Wei He; Yi Luo; Yijun Xu; Xue Bai; Qi Wang; Yujie Huang
Journal:  Front Immunol       Date:  2020-01-08       Impact factor: 7.561

9.  The Insulin Receptor: A Potential Target of Amarogentin Isolated from Gentiana rigescens Franch That Induces Neurogenesis in PC12 Cells.

Authors:  Lihong Cheng; Hiroyuki Osada; Tianyan Xing; Minoru Yoshida; Lan Xiang; Jianhua Qi
Journal:  Biomedicines       Date:  2021-05-20

10.  Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model.

Authors:  Fan Wan; Mengyu Wang; Ruqing Zhong; Liang Chen; Hui Han; Lei Liu; Yong Zhao; Huiyuan Lv; Fujiang Hou; Bao Yi; Hongfu Zhang
Journal:  Front Cell Infect Microbiol       Date:  2022-01-04       Impact factor: 5.293
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