Literature DB >> 27194399

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice.

Hu Zhu1, Dipendra K Aryal1, Reid H J Olsen1, Daniel J Urban1, Amanda Swearingen2, Stacy Forbes2, Bryan L Roth1, Ute Hochgeschwender2.   

Abstract

DREADDs, designer receptors exclusively activated by designer drugs, are engineered G protein-coupled receptors (GPCR) which can precisely control GPCR signaling pathways (for example, Gq, Gs, and Gi). This chemogenetic technology for control of GPCR signaling has been successfully applied in a variety of in vivo studies, including in mice, to remotely control GPCR signaling, for example, in neurons, glia cells, pancreatic β-cells, or cancer cells. In order to fully explore the in vivo applications of the DREADD technology, we generated hM3Dq and hM4Di strains of mice which allow for Cre recombinase-mediated restricted expression of these pathway-selective DREADDs. With the many Cre driver lines now available, these DREADD lines will be applicable to studying a wide array of research and preclinical questions. genesis 54:439-446, 2016.
© 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Entities:  

Keywords:  G protein-coupled receptors; GsD; chemogenetic; hM3Dq; hM4Di

Mesh：

Substances：

Year:  2016        PMID： 27194399      PMCID： PMC4990490          DOI： 10.1002/dvg.22949

Source DB:  PubMed          Journal:  Genesis        ISSN： 1526-954X            Impact factor:   2.487


  20 in total

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