Literature DB >> 27194202

Gymnopeptides A and B, Cyclic Octadecapeptides from the Mushroom Gymnopus fusipes.

Attila Ványolós, Miklós Dékány1, Bernadett Kovács, Balázs Krámos1, Péter Bérdi, István Zupkó, Judit Hohmann, Zoltán Béni1.   

Abstract

Mycochemical study of the mushroom Gymnopus fusipes led to the discovery of two new cyclopeptides. The two compounds, named as gymnopeptides A and B, are unprecedented highly N-methylated cyclic octadecapeptides. Detailed spectroscopic studies, Marfey's analysis, and a preliminary molecular modeling study suggested that both are natural cyclic β hairpins. The isolated compounds exhibited striking antiproliferative activity on several human cancer cell lines, with nanomolar IC50 values.

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Year:  2016        PMID： 27194202     DOI： 10.1021/acs.orglett.6b01158

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control.

Authors:  Suzanne M Batiste; Jeffrey N Johnston
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-14       Impact factor: 11.205

Review 2.  Exploring fungal RiPPs from the perspective of chemical ecology.

Authors:  R E Ford; G D Foster; A M Bailey
Journal:  Fungal Biol Biotechnol       Date:  2022-06-25

Review 3.  Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides.

Authors:  Xiaohan Wang; Minyi Lin; Dan Xu; Daowan Lai; Ligang Zhou
Journal:  Molecules       Date:  2017-11-27       Impact factor: 4.411

Review 4.  Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review.

Authors:  Muna Ali Abdalla; Lyndy J McGaw
Journal:  Molecules       Date:  2018-08-20       Impact factor: 4.411

5.  Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A.

Authors:  Emmanuel Matabaro; Hannelore Kaspar; Paul Dahlin; Daniel L V Bader; Claudia E Murar; Florian Staubli; Christopher M Field; Jeffrey W Bode; Markus Künzler
Journal:  Sci Rep       Date:  2021-02-11       Impact factor: 4.996

6.  Napthrene Compounds from Mycelial Fermentation Products of Marasmius berteroi.

Authors:  Ning Ning Yang; Qing Yun Ma; Fan Dong Kong; Qing Yi Xie; Hao Fu Dai; Li Man Zhou; Zhi Fang Yu; You Xing Zhao
Journal:  Molecules       Date:  2020-08-26       Impact factor: 4.411
  6 in total

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