| Literature DB >> 27194069 |
Pamela Natalia Bellucci1, María Florencia González Bagnes1, Guillermo Di Girolamo2, Claudio Daniel González1.
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of heterogeneous drugs largely known for their anti-inflammatory, antipyretic, and analgesic effects, which are met by means of the inhibition of the cyclooxygenase (COX) enzymes. Even when their use in patients with diabetes mellitus is limited due to relevant adverse events, some pharmacological and metabolic effects of NSAIDs have been further studied to be potentially beneficial in the prevention and/or treatment of diabetic subjects. Effects on endogenous glucose production, peripheral insulin resistance, pancreatic islet, and systemic inflammation and the insulin clearance have been reported. In this article, we overview the scientific literature of the last 5 years regarding the potential effects of NSAID treatment on diabetes prevention/treatment. The selected papers showed information in both humans and animal models. Furthermore, we included papers that suggest new areas for further investigation, and we discussed our own suggestions on this matter.Entities:
Keywords: COX inhibition; NSAIDs; diabetes; inflammation; salsalate
Mesh：
Substances：
Year: 2016 PMID： 27194069 DOI： 10.1177/0897190016649551
Source DB: PubMed Journal: J Pharm Pract ISSN： 0897-1900