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Literature DB >> 27193875

Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four lines.

K Yu Sarkissova¹, I B Fedotova², N M Surina², G M Nikolaev², O V Perepelkina², I I Poletaeva³.

Abstract

Anxiety (Anx) and depression (Dp) levels were evaluated in rats of 4 lines: 2 of them (KM and "4") exhibited audiogenic seizures (AS), and 2 (Wistar and "0") had no AS. In KM rats (with AS), Anx and Dp levels were higher than in Wistars (without AS), while in "4" and "0" rats with the related genetic background but contrasting in AS severity, Anx and Dp indices were not different. Fluoxetine treatment exerted antidepressant effect in all rat lines irrespective of its effect on AS. Thus, phenotypic expression of AS is not directly associated with the mechanisms of Anx and Dp development.

Entities: Chemical Disease Species

Mesh：

Substances：
Fluoxetine

Year: 2016 PMID： 27193875 DOI： 10.1134/S0012496616020058

Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966

13 in total

Review 1. The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression [corrected].

Authors: Karine Sarkisova; Gilles van Luijtelaar
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2010-11-17 Impact factor: 5.067

2. Behavioral characteristics of WAG/Rij rats susceptible and non-susceptible to audiogenic seizures.

Authors: K Yu Sarkisova; M A Kulikov
Journal: Behav Brain Res Date: 2005-09-23 Impact factor: 3.332

3. Convulsive and nonconvulsive epilepsy in rats: effects on behavioral response to novelty stress.

Authors: I S Midzyanovskaya; A B Shatskova; K Yu Sarkisova; G van Luijtelaar; L Tuomisto; G D Kuznetsova
Journal: Epilepsy Behav Date: 2005-04-26 Impact factor: 2.937

4. Relation between startle reactivity and sucrose avidity in two rat strains bred for differential seizure susceptibility.

Authors: Dwayne Runke; Dan C McIntyre; Veronique St-Onge; Krista L Gilby
Journal: Exp Neurol Date: 2011-02-12 Impact factor: 5.330

5. Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation.

Authors: Nigel C Jones; Michael R Salzberg; Gaurav Kumar; Abbie Couper; Margaret J Morris; Terence J O'Brien
Journal: Exp Neurol Date: 2007-10-05 Impact factor: 5.330

2. Clinical Study on Electronic Medical Neuroelectric Stimulation Based on the Internet of Things to Treat Epilepsy Patients with Anxiety and Depression.

Authors: Bo Zhang; Weijie Wang; Shenguo Wang; Shaoping Li; Mingchao Liu; Lantian Wang; Caijun Yang
Journal: J Healthc Eng Date: 2021-03-17 Impact factor: 2.682

2 in total

Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four lines.

Review 1. The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression [corrected].

2. Behavioral characteristics of WAG/Rij rats susceptible and non-susceptible to audiogenic seizures.

3. Convulsive and nonconvulsive epilepsy in rats: effects on behavioral response to novelty stress.

4. Relation between startle reactivity and sucrose avidity in two rat strains bred for differential seizure susceptibility.

5. Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation.

Review 6. Channelopathies in idiopathic epilepsy.

Review 7. Therapeutic potential of fluoxetine in neurological disorders.

8. [Laboratory rat selection for the trait "the absence of audiogenic seizure proneness"].

9. Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.

10. Depressogenic medications and other risk factors for depression among Polish patients with epilepsy.

Review 1. Serotonin and sudden unexpected death in epilepsy.

2. Clinical Study on Electronic Medical Neuroelectric Stimulation Based on the Internet of Things to Treat Epilepsy Patients with Anxiety and Depression.