| Literature DB >> 27193723 |
A V Mishin1, A P Luginina2, A P Potapenko2, V I Borshchevskiy2,3, V Katritch4, E Edelweiss5,6, I S Okhrimenko2, V I Gordeliy2,6,7,8,3, V G Cherezov2,4.
Abstract
In humans, two endothelin receptors, ETa and ETb, are activated by three endogenous 21-mer cyclic peptides, ET-1, ET-2, and ET-3, which control various physiological processes, including vasoconstriction, vasodilation, and stimulation of cell proliferation. The first stage of this study it to produce a stable solubilized and purified receptor in a monodisperse state. This article is focused on the engineering, expression, purification, and characterization of the endothelin receptor B for subsequent structural and functional studies.Entities:
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Year: 2016 PMID： 27193723 DOI： 10.1134/S1607672916020216
Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788