Literature DB >> 27193719

Investigation of the effect of α-melanocyte-stimulating hormone on proliferation and early stages of differentiation of human induced pluripotent stem cells.

E V Novosadova1, E S Manuilova2, E L Arsenyeva2, L A Andreeva2, O S Lebedeva2, I A Grivennikov2, N F Myasoedov2.   

Abstract

We have studied the influence of α-melanocyte-stimulating hormone (α-MSH) on proliferation and early stages of differentiation of human induced pluripotent stem cells (iPSc). We have demonstrated that α-MSH receptor genes are expressed in undifferentiated iPSc. The expression levels of MCR1, MCR2, and MCR3 increased at the embryoid body (EB) formation stage. The formation of neural progenitors was accompanied by elevation of MCR2, MCR3, and MCR4 expression. α-MSH had no effect on EB generation and iPSc proliferation at concentrations ranging from 1 nM to 10 μM. At the same time, α-MSH increased the generation of neural rosettes in human iPSc cultures more than twice.

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Year:  2016        PMID： 27193719     DOI： 10.1134/S1607672916020174

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  9 in total

1.  Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.

Authors:  Oleg V Dolotov; Ekaterina A Karpenko; Tamara S Seredenina; Lyudmila S Inozemtseva; Natalia G Levitskaya; Yuriy A Zolotarev; Andrey A Kamensky; Igor A Grivennikov; Juergen Engele; Nikolay F Myasoedov
Journal:  J Neurochem       Date:  2006-04       Impact factor: 5.372

2.  The heptapeptide SEMAX stimulates BDNF expression in different areas of the rat brain in vivo.

Authors:  O V Dolotov; T S Seredenina; N G Levitskaya; A A Kamensky; L A Andreeva; L Yu Alfeeva; I Yu Nagaev; Yu A Zolotarev; I A Grivennikov; Yu Engele; N F Myasoedov
Journal:  Dokl Biol Sci       Date:  2003 Jul-Aug

3.  The effect of α-melanocyte-stimulating hormone on early stages of differentiation of mouse embryonic stem cells.

Authors:  E S Manuilova; E L Arsen'eva; E V Novosadova; I A Grivennikov; N F Myasoedov
Journal:  Dokl Biol Sci       Date:  2013-11

4.  Melanocortin receptors mediate alpha-MSH-induced stimulation of neurite outgrowth in neuro 2A cells.

Authors:  R A Adan; M van der Kraan; R P Doornbos; P R Bär; J P Burbach; W H Gispen
Journal:  Brain Res Mol Brain Res       Date:  1996-02

Review 5.  ACTH-related peptides: receptors and signal transduction systems involved in their neurotrophic and neuroprotective actions.

Authors:  E M Hol; W H Gispen; P R Bär
Journal:  Peptides       Date:  1995       Impact factor: 3.750

6.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

7.  Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons.

Authors:  Igor A Grivennikov; Oleg V Dolotov; Yuri A Zolotarev; Ludmila A Andreeva; Nikolai F Myasoedov; Lauren Leacher; Ira B Black; Cheryl F Dreyfus
Journal:  Restor Neurol Neurosci       Date:  2008       Impact factor: 2.406

Review 8.  Neuropeptide processing and its impact on melanocortin pathways.

Authors:  Lynn E Pritchard; Anne White
Journal:  Endocrinology       Date:  2007-06-21       Impact factor: 4.736

9.  α-Melanocyte stimulating hormone prevents GABAergic neuronal loss and improves cognitive function in Alzheimer's disease.

Authors:  Keran Ma; JoAnne McLaurin
Journal:  J Neurosci       Date:  2014-05-14       Impact factor: 6.167
  9 in total
  2 in total

1.  Transcriptome datasets of neural progenitors and neurons differentiated from induced pluripotent stem cells of healthy donors and Parkinson's disease patients with mutations in the PARK2 gene.

Authors:  Ekaterina Novosadova; Ksenia Anufrieva; Elizaveta Kazantseva; Elena Arsenyeva; Viya Fedoseyeva; Ekaterina Stepanenko; Daniil Poberezhniy; Sergey Illarioshkin; Lyudmila Novosadova; Tatiana Gerasimova; Valentina Nenasheva; Igor Grivennikov; Maria Lagarkova; Vyacheslav Tarantul
Journal:  Data Brief       Date:  2022-02-16

2.  The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines.

Authors:  Enrica Flori; Eleonora Rosati; Giorgia Cardinali; Daniela Kovacs; Barbara Bellei; Mauro Picardo; Vittoria Maresca
Journal:  J Exp Clin Cancer Res       Date:  2017-10-11
  2 in total

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