Literature DB >> 27193714

Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells.

T N Portseva1, A V Brechalov2, E A Dukhanina2, A G Stepchenko2, E V Pankratova2, S G Georgieva2.   

Abstract

The effect of the transcription factor Oct-1 (POU2F1) on the expression of the tumor cell marker metastasin (Mts1/S100A4) was studied. Comparative analysis of various tumor lines showed no clear correlation between the expression level of Mts1/S100A4 and the content of Oct-1. However, at stable transfection of tumor cells with Oct-1A, Oct-1L, and Oct-1X isoforms we detected an elevated level of Oct-1, which stimulated Mts1/S100A4 secretion. These findings extend our understanding of the molecular mechanisms of the tumorigenic effect of Oct-1.

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Year:  2016        PMID： 27193714     DOI： 10.1134/S1607672916020125

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  14 in total

Review 1.  [Oct-1 transcription factor--plasticity and polyfunctionality].

Authors:  E V Sytina; E V Pankratova
Journal:  Mol Biol (Mosk)       Date:  2003 Sep-Oct

2.  The nucleotide sequence of mouse OCT-1 cDNA.

Authors:  A G Stepchenko
Journal:  Nucleic Acids Res       Date:  1992-03-25       Impact factor: 16.971

3.  A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.

Authors:  Jinsuk Kang; Matthew Gemberling; Mitsuhiro Nakamura; Frank G Whitby; Hiroshi Handa; William G Fairbrother; Dean Tantin
Journal:  Genes Dev       Date:  2009-01-15       Impact factor: 11.361

4.  The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

Authors:  R A Sturm; G Das; W Herr
Journal:  Genes Dev       Date:  1988-12       Impact factor: 11.361

5.  [The new isoform of Oct-1 transcription factor is transcribed from alternative promoter].

Authors:  I D Krylova; T N Portseva; S G Georgieva; A G Stepchenko; E V Pankratova
Journal:  Mol Biol (Mosk)       Date:  2013 Jul-Aug

6.  Opposite roles of metastasin (S100A4) in two potentially tumoricidal mechanisms involving human lymphocyte protein Tag7 and Hsp70.

Authors:  Elena A Dukhanina; Olga D Kabanova; Tamara I Lukyanova; Yury V Shatalov; Denis V Yashin; Elena A Romanova; Nikolai V Gnuchev; Alexander V Galkin; Georgii P Georgiev; Lidia P Sashchenko
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-03       Impact factor: 11.205

7.  The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis.

Authors:  Thamir M Ismail; David G Fernig; Philip S Rudland; Carla J Terry; Guozheng Wang; Roger Barraclough
Journal:  Carcinogenesis       Date:  2008-09-10       Impact factor: 4.944

8.  Evolutionary and functional analysis of the key pluripotency factor Oct4 and its family proteins.

Authors:  Xinmin Zhang; Yuzhen Ma; Xiuying Liu; Qi Zhou; Xiu-Jie Wang
Journal:  J Genet Genomics       Date:  2013-06-13       Impact factor: 4.275

9.  Transcription factor Oct1 is a somatic and cancer stem cell determinant.

Authors:  Jessica Maddox; Arvind Shakya; Samuel South; Dawne Shelton; Jared N Andersen; Stephanie Chidester; Jinsuk Kang; Keith M Gligorich; David A Jones; Gerald J Spangrude; Bryan E Welm; Dean Tantin
Journal:  PLoS Genet       Date:  2012-11-08       Impact factor: 5.917

10.  High expression of octamer transcription factor 1 in cervical cancer.

Authors:  Songshu Xiao; Shan Liao; Yanhong Zhou; Bin Jiang; Yueran Li; Min Xue
Journal:  Oncol Lett       Date:  2014-04-02       Impact factor: 2.967
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