Literature DB >> 27193713

New monoclonal antibodies to the Ebola virus glycoprotein: Identification and analysis of the amino acid sequence of the variable domains.

A A Panina1, T K Aliev2, O B Shemchukova3, I G Dement'yeva3, N E Varlamov3, L P Pozdnyakova3, M N Bokov3, D A Dolgikh4,5, P G Sveshnikov3, M P Kirpichnikov4,5.   

Abstract

We determined the nucleotide and amino acid sequences of variable domains of three new monoclonal antibodies to the glycoprotein of Ebola virus capsid. The framework and hypervariable regions of immunoglobulin heavy and light chains were identified. The primary structures were confirmed using massspectrometry analysis. Immunoglobulin database search showed the uniqueness of the sequences obtained.

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Year:  2016        PMID： 27193713     DOI： 10.1134/S1607672916020113

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  5 in total

1.  Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody.

Authors:  Paul W H I Parren; Tom W Geisbert; Toshiaki Maruyama; Peter B Jahrling; Dennis R Burton
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

2.  Structure of an antibody in complex with its mucin domain linear epitope that is protective against Ebola virus.

Authors:  Daniel Olal; Ana I Kuehne; Shridhar Bale; Peter Halfmann; Takao Hashiguchi; Marnie L Fusco; Jeffrey E Lee; Liam B King; Yoshihiro Kawaoka; John M Dye; Erica Ollmann Saphire
Journal:  J Virol       Date:  2011-12-14       Impact factor: 5.103

3.  Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies.

Authors:  Xiangguo Qiu; Jonathan Audet; Gary Wong; Stephane Pillet; Alexander Bello; Teresa Cabral; Jim E Strong; Frank Plummer; Cindy R Corbett; Judie B Alimonti; Gary P Kobinger
Journal:  Sci Transl Med       Date:  2012-06-13       Impact factor: 17.956

4.  Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.

Authors:  Gene Garrard Olinger; James Pettitt; Do Kim; Cara Working; Ognian Bohorov; Barry Bratcher; Ernie Hiatt; Steven D Hume; Ashley K Johnson; Josh Morton; Michael Pauly; Kevin J Whaley; Calli M Lear; Julia E Biggins; Corinne Scully; Lisa Hensley; Larry Zeitlin
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-15       Impact factor: 11.205

5.  Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.

Authors:  Xiangguo Qiu; Gary Wong; Jonathan Audet; Alexander Bello; Lisa Fernando; Judie B Alimonti; Hugues Fausther-Bovendo; Haiyan Wei; Jenna Aviles; Ernie Hiatt; Ashley Johnson; Josh Morton; Kelsi Swope; Ognian Bohorov; Natasha Bohorova; Charles Goodman; Do Kim; Michael H Pauly; Jesus Velasco; James Pettitt; Gene G Olinger; Kevin Whaley; Bianli Xu; James E Strong; Larry Zeitlin; Gary P Kobinger
Journal:  Nature       Date:  2014-08-29       Impact factor: 49.962
  5 in total
  1 in total

1.  Recombinant Antibodies to the Ebola Virus Glycoprotein.

Authors:  A A Panina; I G Dementieva; T K Aliev; V A Toporova; D S Balabashin; M N Bokov; L P Pozdnyakova; O B Shchemchukova; D A Dolgikh; P G Sveshnikov; M P Kirpichnikov
Journal:  Acta Naturae       Date:  2017 Oct-Dec       Impact factor: 1.845
  1 in total

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