| Literature DB >> 27193711 |
M G Sharapov1, S V Gudkov2,3,4,5, A E Gordeeva6,4, O E Karp2, V E Ivanov2, O V Shelkovskaya2,4, V I Bruskov2,4, V I Novoselov6,4, E E Fesenko6.
Abstract
After injection of 20 mg/kg peroxiredoxin 6 to male Kv:SHK mice 15 min before X-ray irradiation in the range of lethal doses (7-10 Gy), the mice remained alive for 30 days, whereas the mortality of the control animals was 100%. In the irradiated animals, peroxiredoxin 6 decreased the severity of radiation-induced leucopenia, granulocytopenia, and thrombocytopenia, increased the number of blood corpuscles, and prevented the mass death of epithelial cells and the destruction of the small intestine. Thus, peroxiredoxin 6 can be regarded as a prophylactic radioprotective agent.Entities:
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Year: 2016 PMID： 27193711 DOI： 10.1134/S1607672916020095
Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788