Literature DB >> 27193709

The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na(+) transport in frog skin.

Z I Krutetskaya1, A V Melnitskaya2, V G Antonov2, A D Nozdrachev2.   

Abstract

Using voltage-clamp technique, the involvement of WASP proteins and Arp2/3 complex in the effect of immunomodulator drug glutoxim on Na(+) transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with the N-WASP inhibitor wiskostatin or the Arp2/3 complex inhibitor CK-0944666 significantly decreases the stimulatory effect of glutoxim on Na(+) transport. The data suggest the involvement of actin filament polymerization and branching in the glutoxim effect on Na(+) transport in frog skin.

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Year:  2016        PMID： 27193709     DOI： 10.1134/S1607672916020071

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  10 in total

Review 1.  [Structural and functional organization of Na+ transport in epithelial systems. I. Epithelial Na+ channels].

Authors:  A V Mel'nitskaia; Z I Krutetskaia; O E Lebedev
Journal:  Tsitologiia       Date:  2006

2.  Inhibitors of the cyclooxygenase oxidation pathway of arachidonic acid suppress the stimulating effect of glutoxim on Na(+) transport in frog skin.

Authors:  Z I Krutetskaya; A V Mel'nitskaya; V G Antonov; A D Nozdrachev
Journal:  Dokl Biol Sci       Date:  2013-08-24

3.  Effect of disulfide-containing compounds on the Na+ transport in the frog skin.

Authors:  Z I Krutetskaya; O E Lebedev; A V Mel'nitskaya; V G Antonov; A D Nozdrachev
Journal:  Dokl Biol Sci       Date:  2008 Jul-Aug

4.  Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex.

Authors:  Daria V Ilatovskaya; Tengis S Pavlov; Vladislav Levchenko; Yuri A Negulyaev; Alexander Staruschenko
Journal:  FASEB J       Date:  2011-05-02       Impact factor: 5.191

5.  Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel.

Authors:  Alexey V Karpushev; Vladislav Levchenko; Daria V Ilatovskaya; Tengis S Pavlov; Alexander Staruschenko
Journal:  Hypertension       Date:  2011-04-04       Impact factor: 10.190

6.  Sodium-dependent regulation of epithelial sodium channel densities in frog skin; a role for the cytoskeleton.

Authors:  W J Els; K Y Chou
Journal:  J Physiol       Date:  1993-03       Impact factor: 5.182

7.  Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.

Authors:  Jeffrey R Peterson; Lincoln C Bickford; David Morgan; Annette S Kim; Ouathek Ouerfelli; Marc W Kirschner; Michael K Rosen
Journal:  Nat Struct Mol Biol       Date:  2004-07-04       Impact factor: 15.369

8.  Mutational analysis of cysteine-rich domains of the epithelium sodium channel (ENaC). Identification of cysteines essential for channel expression at the cell surface.

Authors:  D Firsov; M Robert-Nicoud; S Gruender; L Schild; B C Rossier
Journal:  J Biol Chem       Date:  1999-01-29       Impact factor: 5.157

Review 9.  Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation.

Authors:  Gerben Bouma; Siobhan O Burns; Adrian J Thrasher
Journal:  Immunobiology       Date:  2009-07-22       Impact factor: 3.144

10.  Characterization of two classes of small molecule inhibitors of Arp2/3 complex.

Authors:  B J Nolen; N Tomasevic; A Russell; D W Pierce; Z Jia; C D McCormick; J Hartman; R Sakowicz; T D Pollard
Journal:  Nature       Date:  2009-08-02       Impact factor: 49.962
  10 in total

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