Literature DB >> 27193703

N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress.

A M Ashba1, M G Akimov2, N M Gretskaya1, V V Bezuglov1.   

Abstract

It was shown that dopamine amides of arachidonic, oleic, and docosahexaenoic acids exhibit toxicity with respect to PC12 pheochromocytoma cell line. The mechanism of realization of the cytotoxic effect of acyl dopamines is the induction of oxidative stress. This event is preceded by triggering the synthesis of nitric oxide.

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Year:  2016        PMID： 27193703     DOI： 10.1134/S1607672916020010

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  10 in total

1.  Measurement of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT.

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2.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
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3.  Cytotoxicity of Endogenous Lipids N-acyl Dopamines and their Possible Metabolic Derivatives for Human Cancer Cell Lines of Different Histological Origin.

Authors:  Mikhail G Akimov; Natalia M Gretskaya; Galina N Zinchenko; Vladimir V Bezuglov
Journal:  Anticancer Res       Date:  2015-05       Impact factor: 2.480

4.  N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.

Authors:  T Bisogno; D Melck; N M Gretskaya; V V Bezuglov; L De Petrocellis; V Di Marzo
Journal:  Biochem J       Date:  2000-11-01       Impact factor: 3.857

Review 5.  Apoptotic cell death and nitric oxide: activating and antagonistic transducing pathways.

Authors:  B Brüne; K Sandau; A von Knethen
Journal:  Biochemistry (Mosc)       Date:  1998-07       Impact factor: 2.487

6.  Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism.

Authors:  Jake Jacobson; Michael R Duchen; John Hothersall; John B Clark; Simon J R Heales
Journal:  J Neurochem       Date:  2005-08-16       Impact factor: 5.372

7.  Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferation.

Authors:  Sumner Burstein; Rebecca Salmonsen
Journal:  Bioorg Med Chem       Date:  2008-10-11       Impact factor: 3.641

8.  Possible endocannabinoid control of colorectal cancer growth.

Authors:  Alessia Ligresti; Tiziana Bisogno; Isabel Matias; Luciano De Petrocellis; Maria Grazia Cascio; Vittorio Cosenza; Giuseppe D'argenio; Giuseppe Scaglione; Maurizio Bifulco; Italo Sorrentini; Vincenzo Di Marzo
Journal:  Gastroenterology       Date:  2003-09       Impact factor: 22.682

9.  Antioxidant and neuroprotective properties of N-arachidonoyldopamine.

Authors:  Mikhail Yu Bobrov; Anatoly A Lizhin; Ekaterina L Andrianova; Natalia M Gretskaya; Lidia E Frumkina; Leonid G Khaspekov; Vladimir V Bezuglov
Journal:  Neurosci Lett       Date:  2007-11-09       Impact factor: 3.046

10.  Formation of dopamine adducts derived from brain polyunsaturated fatty acids: mechanism for Parkinson disease.

Authors:  Xuebo Liu; Naruomi Yamada; Wakako Maruyama; Toshihiko Osawa
Journal:  J Biol Chem       Date:  2008-10-15       Impact factor: 5.157
  10 in total
  1 in total

1.  N-acyl dopamines induce apoptosis in PC12 cell line via the GPR55 receptor activation.

Authors:  M G Akimov; A M Ashba; N M Gretskaya; V V Bezuglov
Journal:  Dokl Biochem Biophys       Date:  2017-07-20       Impact factor: 0.788
  1 in total

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