J A Johnson1, P J O'Halloran2, D Crimmins3, J Caird3. 1. Department of Neurological Surgery, Cork University Hospital, Corcaigh, Ireland. 2. Department of Neurological Surgery, Cork University Hospital, Corcaigh, Ireland. phiohalloran@rcsi.ie. 3. Department of Paediatric Neurosurgery, Children's University Hospital, Temple Street, Dublin 1, Ireland.
Abstract
INTRODUCTION: Ventriculoperitoneal (VP) shunt insertion is the most common cerebrospinal fluid (CSF) diversionary procedure used for the treatment of chronic hydrocephalus. Sterile CSF ascites is a rare complication of VP shunt insertion. This can arise from either an overproduction of CSF or inadequate filtration of CSF at the level of the peritoneum. By either mechanism, the development of CSF ascites requires an intact VP shunt. OBJECTIVE: The authors discuss two paediatric cases diagnosed with suprasellar pilocytic astrocytomas treated with platinum-based chemotherapy, who subsequently developed sterile CSF ascites. We review the literature with regard to CSF malabsorption and discuss it as a contributing factor to shunt malfunction. CONCLUSION: CSF malabsorption with resultant ascites is a rare complication of VP shunting with many etiologies. Two common predisposing factors included the use of platinum-based chemotherapeutic agents, as well as the specific neuropathology. Further analysis of these two entities is needed in order to elucidate their role in contributing to the development of CSF ascites in this patient cohort.
INTRODUCTION: Ventriculoperitoneal (VP) shunt insertion is the most common cerebrospinal fluid (CSF) diversionary procedure used for the treatment of chronic hydrocephalus. Sterile CSF ascites is a rare complication of VP shunt insertion. This can arise from either an overproduction of CSF or inadequate filtration of CSF at the level of the peritoneum. By either mechanism, the development of CSF ascites requires an intact VP shunt. OBJECTIVE: The authors discuss two paediatric cases diagnosed with suprasellar pilocytic astrocytomas treated with platinum-based chemotherapy, who subsequently developed sterile CSF ascites. We review the literature with regard to CSF malabsorption and discuss it as a contributing factor to shunt malfunction. CONCLUSION:CSF malabsorption with resultant ascites is a rare complication of VP shunting with many etiologies. Two common predisposing factors included the use of platinum-based chemotherapeutic agents, as well as the specific neuropathology. Further analysis of these two entities is needed in order to elucidate their role in contributing to the development of CSF ascites in this patient cohort.
Authors: Arne Warth; Perikles Simon; David Capper; Benjamin Goeppert; Ghazaleh Tabatabai; Hajo Herzog; Klaus Dietz; Florian Stubenvoll; Rami Ajaaj; Ralf Becker; Michael Weller; Richard Meyermann; Hartwig Wolburg; Michel Mittelbronn Journal: J Neurosci Res Date: 2007-05-01 Impact factor: 4.164
Authors: F Elferink; W J van der Vijgh; I Klein; W W ten Bokkel Huinink; R Dubbelman; J G McVie Journal: Cancer Chemother Pharmacol Date: 1988 Impact factor: 3.333