Literature DB >> 27190932

Anogenital Pruritus - An Overview.

Murugan Swamiappan1.   

Abstract

Anogenital pruritus is defined as intense itching, acute or chronic, affecting the anal, perianal, perineal and genital skin, which is a dominant problem in the course of various cutaneous and systemic conditions. It is one of the common, extremely annoying symptom for which patients attend the Dermatology Outpatient Department (OPD). Anogenital skin is highly sensitive to soaps, perfumes, clothing and superficial trauma and it is more prone for itchy dermatoses as a result of warmth, friction, lack of aeration, sweating and occlusive inner garments. Anogenital pruritus is associated with a wide spectrum of diseases which includes localized infections, infestations, inflammatory dermatoses, allergic and irritant conditions, anorectal diseases, systemic causes, nutritional disorders, psychological and when the cause cannot be found out it is often termed idiopathic. Patients are highly reluctant in consulting the physician for anogenital itch in the early stage, they usually present at a later stage with either atypical manifestations or depigmentation and lichenification, secondary to constant scratching. They often resort to over the counter topical agents, particularly combination products which contain topical steroids. The irrational use of such products results in complications like skin atrophy, striae, incognito etc. A proper clinical history, clinical examination, investigations like scrapping for fungus and itch mite, skin biopsy, patch test and relevant blood investigations to rule out systemic conditions should be carried out, when needed, to arrive at an accurate diagnosis, before treating the patient.

Entities:  

Keywords:  Causes; Evaluation; Lichenification; Management; Priritus ani; Pruritus vulvae

Year:  2016        PMID: 27190932      PMCID: PMC4866230          DOI: 10.7860/JCDR/2016/18440.7703

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  29 in total

Review 1.  Topical therapies for pruritus.

Authors:  Sarina B Elmariah; Ethan A Lerner
Journal:  Semin Cutan Med Surg       Date:  2011-06

Review 2.  Itch signaling in the nervous system.

Authors:  Joseph Jeffry; Seungil Kim; Zhou-Feng Chen
Journal:  Physiology (Bethesda)       Date:  2011-08

3.  TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.

Authors:  Won-Sik Shim; Min-Ho Tak; Mi-Hyun Lee; Minjung Kim; Minkyung Kim; Jae-Yeon Koo; Chang-Hun Lee; Misook Kim; Uhtaek Oh
Journal:  J Neurosci       Date:  2007-02-28       Impact factor: 6.167

Review 4.  Itch mechanisms and circuits.

Authors:  Liang Han; Xinzhong Dong
Journal:  Annu Rev Biophys       Date:  2014       Impact factor: 12.981

5.  Four Possible Itching Pathways Related to the TRPV1 Channel, Histamine, PAR-2 and Serotonin.

Authors:  Hiroshi Nakagawa; Akio Hiura
Journal:  Malays J Med Sci       Date:  2013-07

6.  Pruritus ani. Causes and concerns.

Authors:  G L Daniel; W E Longo; A M Vernava
Journal:  Dis Colon Rectum       Date:  1994-07       Impact factor: 4.585

Review 7.  An approach to the treatment of anogenital pruritus.

Authors:  Gabriele E Weichert
Journal:  Dermatol Ther       Date:  2004       Impact factor: 2.851

8.  Pimecrolimus 1% cream for pruritus in postmenopausal diabetic women with vulvar lichen simplex chronicus: a prospective non-controlled case series.

Authors:  Handan Kiymet Kelekci; Hikmet Gulsen Uncu; Bulent Yilmaz; Orcun Ozdemir; Necdet Sut; Sefa Kelekci
Journal:  J Dermatolog Treat       Date:  2008       Impact factor: 3.359

Review 9.  Itch: scratching more than the surface.

Authors:  R Twycross; M W Greaves; H Handwerker; E A Jones; S E Libretto; J C Szepietowski; Z Zylicz
Journal:  QJM       Date:  2003-01

10.  Gluten-sensitive enteropathy associated with genital lichen simplex chronicus.

Authors:  Joanna E Gach; Henry Francis Seddon
Journal:  JRSM Short Rep       Date:  2010-10-21
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  4 in total

1.  [Establishment of a SD rat model of vulvar lichen simplex chronicus and detection of the expression of protease activated receptor 2].

Authors:  Huan Yang; Zhen-Hua Fu; Hua-Jun Tang; Cheng-Zhi Li
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2017-01-20

Review 2.  Vulvar pruritus-Causes, Diagnosis and Therapeutic Approach.

Authors:  Linn Woelber; Katharina Prieske; Werner Mendling; Barbara Schmalfeldt; Hans-Jürgen Tietz; Anna Jaeger
Journal:  Dtsch Arztebl Int       Date:  2020-02-21       Impact factor: 5.594

Review 3.  Candida albicans-The Virulence Factors and Clinical Manifestations of Infection.

Authors:  Jasminka Talapko; Martina Juzbašić; Tatjana Matijević; Emina Pustijanac; Sanja Bekić; Ivan Kotris; Ivana Škrlec
Journal:  J Fungi (Basel)       Date:  2021-01-22

Review 4.  Managing Dermatologic Effects of Gender-Affirming Therapy in Transgender Adolescents.

Authors:  Christina Huang; Sarah Gold; Rakan Radi; Seth Amos; Howa Yeung
Journal:  Adolesc Health Med Ther       Date:  2022-10-07
  4 in total

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